Published Erratum
doi: 10.1038/s41467-025-63507-x.
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Kate Lawrenson #
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, Siddhartha Kar #
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, Karen McCue
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, Karoline Kuchenbaeker
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, Kyriaki Michailidou
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, Jonathan Tyrer
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, Jonathan Beesley
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, Susan J Ramus
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, Qiyuan Li
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, Melissa K Delgado
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, Janet M Lee
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, Kristiina Aittomäki
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, Irene L Andrulis
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, Hoda Anton-Culver
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, Volker Arndt
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, Banu K Arun
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, Brita Arver
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, Elisa V Bandera
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, Monica Barile
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, Rosa B Barkardottir
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, Daniel Barrowdale
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, Matthias W Beckmann
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, Javier Benitez
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, Andrew Berchuck
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, Maria Bisogna
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, Line Bjorge
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, Carl Blomqvist
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, William Blot
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, Natalia Bogdanova
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, Anders Bojesen
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, Stig E Bojesen
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, Manjeet K Bolla
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, Bernardo Bonanni
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, Anne-Lise Børresen-Dale
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, Hiltrud Brauch
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, Paul Brennan
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, Hermann Brenner
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, Fiona Bruinsma
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, Joan Brunet
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, Shaik Ahmad Buhari
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, Barbara Burwinkel
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, Ralf Butzow
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, Saundra S Buys
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, Qiuyin Cai
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, Trinidad Caldes
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, Ian Campbell
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, Rikki Cannioto
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, Jenny Chang-Claude
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, Jocelyne Chiquette
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, Ji-Yeob Choi
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, Kathleen B M Claes
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; GEMO Study Collaborators; Linda S Cook
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, Angela Cox
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, Daniel W Cramer
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, Simon S Cross
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, Cezary Cybulski
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, Kamila Czene
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, Mary B Daly
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, Francesca Damiola
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, Agnieszka Dansonka-Mieszkowska
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, Hatef Darabi
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, Joe Dennis
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, Peter Devilee
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, Orland Diez
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, Jennifer A Doherty
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, Susan M Domchek
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, Cecilia M Dorfling
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, Thilo Dörk
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, Martine Dumont
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, Hans Ehrencrona
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, Bent Ejlertsen
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, Steve Ellis
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; EMBRACE; Christoph Engel
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, Eunjung Lee
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, D Gareth Evans
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, Peter A Fasching
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, Lidia Feliubadalo
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, Jonine Figueroa
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, Dieter Flesch-Janys
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, Olivia Fletcher
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, Henrik Flyger
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, Lenka Foretova
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, Florentia Fostira
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, William D Foulkes
89
, Brooke L Fridley
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, Eitan Friedman
91
, Debra Frost
5
, Gaetana Gambino
92
, Patricia A Ganz
93
, Judy Garber
94
, Montserrat García-Closas
81
95
, Aleksandra Gentry-Maharaj
96
, Maya Ghoussaini
3
, Graham G Giles
40
97
, Rosalind Glasspool
98
, Andrew K Godwin
99
, Mark S Goldberg
100
101
, David E Goldgar
102
, Anna González-Neira
19
, Ellen L Goode
103
, Marc T Goodman
104
105
, Mark H Greene
106
, Jacek Gronwald
107
, Pascal Guénel
108
109
, Christopher A Haiman
1
, Per Hall
63
, Emily Hallberg
103
, Ute Hamann
110
, Thomas V O Hansen
111
, Patricia A Harrington
112
, Mikael Hartman
42
113
, Norhashimah Hassan
114
115
, Sue Healey
4
; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Florian Heitz
116
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, Josef Herzog
118
, Estrid Høgdall
119
120
, Claus K Høgdall
121
, Frans B L Hogervorst
122
, Antoinette Hollestelle
123
, John L Hopper
97
, Peter J Hulick
124
, Tomasz Huzarski
62
, Evgeny N Imyanitov
125
; KConFab Investigators; Australian Ovarian Cancer Study Group; Claudine Isaacs
126
, Hidemi Ito
127
, Anna Jakubowska
62
, Ramunas Janavicius
128
, Allan Jensen
121
, Esther M John
129
, Nichola Johnson
84
85
, Maria Kabisch
110
, Daehee Kang
54
55
130
, Miroslav Kapuscinski
131
, Beth Y Karlan
132
, Sofia Khan
45
, Lambertus A Kiemeney
133
, Susanne Kruger Kjaer
120
121
, Julia A Knight
134
135
, Irene Konstantopoulou
88
, Veli-Matti Kosma
136
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, Vessela Kristensen
33
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139
, Jolanta Kupryjanczyk
66
, Ava Kwong
140
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, Miguel de la Hoya
48
, Yael Laitman
91
, Diether Lambrechts
142
143
, Nhu Le
1
, Kim De Leeneer
56
, Jenny Lester
132
, Douglas A Levine
22
, Jingmei Li
63
, Annika Lindblom
144
, Jirong Long
26
, Artitaya Lophatananon
145
, Jennifer T Loud
106
, Karen Lu
146
, Jan Lubinski
62
, Arto Mannermaa
136
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138
, Siranoush Manoukian
147
, Loic Le Marchand
148
, Sara Margolin
149
, Frederik Marme
44
150
, Leon F A G Massuger
151
, Keitaro Matsuo
152
, Sylvie Mazoyer
65
, Lesley McGuffog
5
, Catriona McLean
153
, Iain McNeish
154
, Alfons Meindl
155
, Usha Menon
96
, Arjen R Mensenkamp
156
, Roger L Milne
40
97
, Marco Montagna
157
, Kirsten B Moysich
158
, Kenneth Muir
145
159
, Anna Marie Mulligan
160
161
, Katherine L Nathanson
71
, Roberta B Ness
162
, Susan L Neuhausen
163
, Heli Nevanlinna
45
, Silje Nord
34
, Robert L Nussbaum
164
, Kunle Odunsi
165
, Kenneth Offit
166
, Edith Olah
167
, Olufunmilayo I Olopade
168
, Janet E Olson
103
, Curtis Olswold
103
, David O'Malley
169
, Irene Orlow
170
, Nick Orr
84
, Ana Osorio
171
172
, Sue Kyung Park
55
130
173
, Celeste L Pearce
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, Tanja Pejovic
174
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, Paolo Peterlongo
176
, Georg Pfeiler
177
, Catherine M Phelan
178
, Elizabeth M Poole
179
180
, Katri Pylkäs
181
182
, Paolo Radice
183
, Johanna Rantala
184
, Muhammad Usman Rashid
110
185
, Gad Rennert
186
, Valerie Rhenius
3
, Kerstin Rhiem
187
, Harvey A Risch
188
, Gus Rodriguez
189
, Mary Anne Rossing
190
191
, Anja Rudolph
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, Helga B Salvesen
23
24
, Suleeporn Sangrajrang
192
, Elinor J Sawyer
193
, Joellen M Schildkraut
194
195
, Marjanka K Schmidt
196
, Rita K Schmutzler
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, Thomas A Sellers
178
, Caroline Seynaeve
123
, Mitul Shah
3
, Chen-Yang Shen
201
202
, Xiao-Ou Shu
26
, Weiva Sieh
203
, Christian F Singer
177
, Olga M Sinilnikova
204
205
, Susan Slager
103
, Honglin Song
3
, Penny Soucy
73
, Melissa C Southey
206
, Marie Stenmark-Askmalm
75
207
, Dominique Stoppa-Lyonnet
208
209
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, Christian Sutter
211
, Anthony Swerdlow
85
95
, Sandrine Tchatchou
9
, Manuel R Teixeira
212
213
, Soo H Teo
114
115
, Kathryn L Terry
59
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, Mary Beth Terry
214
, Mads Thomassen
215
, Maria Grazia Tibiletti
216
, Laima Tihomirova
217
, Silvia Tognazzo
218
, Amanda Ewart Toland
219
, Ian Tomlinson
220
, Diana Torres
110
221
, Thérèse Truong
108
109
, Chiu-Chen Tseng
1
, Nadine Tung
222
, Shelley S Tworoger
179
180
, Celine Vachon
103
, Ans M W van den Ouweland
223
, Helena C van Doorn
224
, Elizabeth J van Rensburg
72
, Laura J Van't Veer
196
, Adriaan Vanderstichele
225
, Ignace Vergote
225
, Joseph Vijai
166
, Qin Wang
5
, Shan Wang-Gohrke
226
, Jeffrey N Weitzel
118
, Nicolas Wentzensen
227
, Alice S Whittemore
203
, Hans Wildiers
228
, Robert Winqvist
181
182
, Anna H Wu
1
, Drakoulis Yannoukakos
229
, Sook-Yee Yoon
230
231
, Jyh-Cherng Yu
232
, Wei Zheng
26
, Ying Zheng
233
, Kum Kum Khanna
4
, Jacques Simard
73
, Alvaro N Monteiro
234
, Juliet D French
4
, Fergus J Couch
103
235
, Matthew L Freedman
7
, Douglas F Easton
3
5
, Alison M Dunning
3
, Paul D Pharoah
3
, Stacey L Edwards
4
, Georgia Chenevix-Trench
4
, Antonis C Antoniou
236
, Simon A Gayther
1
237
Collaborators,
Affiliations
Collaborators
-
GEMO Study Collaborators:
Marie-Agnès Collonge-Rame, Alexandre Damette, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy, Pascaline Berthet, Dominique Vaur, Laurent Castera, Sandra Fert Ferrer, Yves-Jean Bignon, Nancy Uhrhammer, Fanny Coron, Laurence Faivre, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Sarab Lizard, Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon, Jean-Philippe Peyrat, Joëlle Fournier, Françoise Révillion, Claude Adenis, Laurence Vénat-Bouvet, Mélanie Léone, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Carole Verny-Pierre, Christine Lasset, Valérie Bonadona, Laure Barjhoux, Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, Isabelle Coupier, Pascal Pujol, Johanna Sokolowska, Myriam Bronner, Capucine Delnatte, Stéphane Bézieau, Véronique Mari, Marion Gauthier-Villars, Bruno Buecher, Etienne Rouleau, Lisa Golmard, Virginie Moncoutier, Muriel Belotti, Antoine de Pauw, Camille Elan, Emmanuelle Fourme, Anne-Marie Birot, Claire Saule, Maïté Laurent, Claude Houdayer, Fabienne Lesueur, Noura Mebirouk, Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin, Fabienne Prieur, Marine Lebrun, Caroline Kientz, Danièle Muller, Jean-Pierre Fricker, Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel, Isabelle Mortemousque, Brigitte Bressac-de-Paillerets, Olivier Caron, Marine Guillaud-Bataille
- EMBRACE:
-
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON):
M A Rookus, F E van Leeuwen, L E van der Kolk, M K Schmidt, N S Russell, J L de Lange, R Wijnands, J M Collée, M J Hooning, C Seynaeve, C H M van Deurzen, I M Obdeijn, C J van Asperen, R A E M Tollenaar, T C T E F van Cronenburg, C M Kets, M G E M Ausems, C C van der Pol, T A M van Os, Q Waisfisz, H E J Meijers-Heijboer, E B Gómez-Garcia, J C Oosterwijk, M J Mourits, G H de Bock, H F Vasen, S Siesling, J Verloop, L I H Overbeek
- KConFab Investigators:
- Australian Ovarian Cancer Study Group:
Affiliations
- 1 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
- 2 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 3 Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
- 4 QIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
- 5 Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
- 6 Medical College, Xiamen University, Xiamen, 361102, China.
- 7 Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
- 8 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, 00029 HUS, Finland.
- 9 Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
- 10 Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada.
- 11 Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, 92697, California, USA.
- 12 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 13 University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
- 14 Department of Oncology, Karolinska University Hospital, Stockholm, 171 77, Sweden.
- 15 Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, 08903, New Jersey, USA.
- 16 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, 20141, Italy.
- 17 Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, 600169-2039, Iceland.
- 18 Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, 91054, Germany.
- 19 Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, E-28029, Spain.
- 20 Centro de Investigación en Red de Enfermedades Raras, Valencia, 28029, Spain.
- 21 Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, North Carolina, USA.
- 22 Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
- 23 Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
- 24 Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, N-5020, Norway.
- 25 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, FIN-00029, Finland.
- 26 Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
- 27 International Epidemiology Institute, Rockville, 20850, Maryland, USA.
- 28 Gynaecology Research Unit, Hannover Medical School, Hannover, D-30625, Germany.
- 29 Department of Clinical Genetics, Vejle Hospital, Vejle, 7100, Denmark.
- 30 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
- 31 Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 32 Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 33 Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, N-0310, Norway.
- 34 K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, N-0310, Norway.
- 35 Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, D-70376, Germany.
- 36 University of Tübingen, Tübingen, 72074, Germany.
- 37 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 38 International Agency for Research on Cancer, Lyon, 69008, France.
- 39 Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
- 40 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Victoria, Australia.
- 41 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, 08908, Spain.
- 42 Department of Surgery, National University Health System, Singapore, 119077, Singapore.
- 43 Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 44 Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
- 45 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
- 46 Department of Pathology, Helsinki University Central Hospital, Helsinki, 00029, Finland.
- 47 Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84112, Utah, USA.
- 48 Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, 28040, Spain.
- 49 Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, 3002, Victoria, Australia.
- 50 Division of Cancer Prevention and Population Sciences, Cancer Pathology & Prevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, 14263, New York, USA.
- 51 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
- 52 University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 53 Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Québec City, G1J 1Z4, Québec, Canada.
- 54 Cancer Research Institute, Seoul National University, Seoul, 08826, Korea.
- 55 Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
- 56 Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.
- 57 Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, 87131, New Mexico, USA.
- 58 Department of Oncology, Sheffield Cancer Research, University of Sheffield, Sheffield, S10 2TN, UK.
- 59 Harvard HT Chan School of Public Health, Boston, 02115, Massachusetts, USA.
- 60 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
- 61 Department of Neuroscience, Academic Unit of Pathology, University of Sheffield, Sheffield, S10 2TN, UK.
- 62 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
- 63 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 64 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, 19111, Pennsylvania, USA.
- 65 INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, 69373, France.
- 66 Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, 44-101, Poland.
- 67 Department of Pathology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
- 68 Department of Human Genetics, Leiden University Medical Center, Leiden, 2333, The Netherlands.
- 69 Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, 08035, Spain.
- 70 Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, 03755, New Hampshire, USA.
- 71 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA.
- 72 Department of Genetics, University of Pretoria, Pretoria, 0083, South Africa.
- 73 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, G1V 4G2, Québec, Canada.
- 74 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 751 05, Sweden.
- 75 Department of Clinical Genetics, Lund University Hospital, Lund, 221 00, Sweden.
- 76 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
- 77 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, 04107, Germany.
- 78 Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9PL, UK.
- 79 Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, 90095, California, USA.
- 80 Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, Barcelona, 08908, Spain.
- 81 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, 20892, Maryland, USA.
- 82 Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 83 Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 84 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
- 85 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
- 86 Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 87 Masaryk Memorial Cancer Institute and Medical Faculty MU, Brno, 625 00, Czech Republic.
- 88 Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, 153 10, Greece.
- 89 Departments of Human Genetics and Oncology, Program in Cancer Genetics, McGill University, Montreal, Montreal, H2W 1S6, Quebec, Canada.
- 90 Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
- 91 Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, 52621, Israel.
- 92 Department of Laboratory Medicine, Section of Genetic Oncology, University and University Hospital of Pisa, Pisa, 56126, Italy.
- 93 Division of Cancer Prevention & Control Research, UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, 90024, California, USA.
- 94 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
- 95 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
- 96 Women's Cancer, UCL EGA Institute for Women's Health, London, WC1E 6AU, UK.
- 97 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Victoria, Australia.
- 98 Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK.
- 99 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
- 100 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, H3A 1A1, Québec, Canada.
- 101 Department of Medicine, McGill University, Montreal, H3A 1A1, Québec, Canada.
- 102 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84132, Utah, USA.
- 103 Department of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
- 104 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 105 Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 106 Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, 20892, Maryland, USA.
- 107 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-204, Poland.
- 108 Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, 94805, France.
- 109 University Paris-Sud, Villejuif, 91405, France.
- 110 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 111 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
- 112 Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
- 113 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 119077, Singapore.
- 114 Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, 50603, Malaysia.
- 115 Cancer Research Initiatives Foundation, Subang Jaya, Selangor, 47500, Malaysia.
- 116 Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, 45136, Germany.
- 117 Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, Wiesbaden, 65199, Germany.
- 118 Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, 91010, California, USA.
- 119 Department of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen, Copenhagen, 2730, Denmark.
- 120 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, DK-2100, Denmark.
- 121 Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark.
- 122 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, 1006, The Netherlands.
- 123 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015, The Netherlands.
- 124 Center for Medical Genetics, NorthShore University Health System, Evanston, 60201, Illinois, USA.
- 125 N.N. Petrov Institute of Oncology, St Petersburg, 197758, Russia.
- 126 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, 20057, District of Columbia, USA.
- 127 Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, 464-8681, Japan.
- 128 State Research Institute Centre for Innovative Medicine, Vilnius, LT-01102, Lithuania.
- 129 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, 94538, California, USA.
- 130 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 08826, Korea.
- 131 Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, 3010, Victoria, Australia.
- 132 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 133 Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, 6500, The Netherlands.
- 134 Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
- 135 Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, M5T 3M7, Ontario, Canada.
- 136 Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, 70210, Finland.
- 137 Cancer Center, Kuopio University Hospital, Kuopio, 70210, Finland.
- 138 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
- 139 Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, 1478, Oslo, Norway.
- 140 The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China.
- 141 Department of Surgery, The University of Hong Kong, Hong Kong, China.
- 142 Vesalius Research Center, VIB, Leuven, 3000, Belgium.
- 143 Department of Oncology, Laboratory for Translational Genetics, University of Leuven, Leuven, 3000, Belgium.
- 144 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 145 Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, CV4 7AL, UK.
- 146 Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
- 147 Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, 20133, Italy.
- 148 University of Hawaii Cancer Center, Honolulu, 96813, Hawaii, USA.
- 149 Department of Oncology - Pathology, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 150 National Center for Tumour Diseases, University of Heidelberg, Heidelberg, 69117, Germany.
- 151 Department of Gynaecology, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
- 152 Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, 812-8582, Japan.
- 153 Anatomical Pathology, The Alfred Hospital, Melbourne, 3004, Victoria, Australia.
- 154 Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK.
- 155 Division of Gynaecology and Obstetrics, Technische Universität München, Munich, 81675, Germany.
- 156 Department of Human Genetics, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
- 157 Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS, Padua, 35128, Italy.
- 158 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
- 159 Institute of Population Health, University of Manchester, Manchester, M13 9PL, UK.
- 160 Laboratory Medicine Program, University Health Network, Toronto, M5G 1L7, Ontario, Canada.
- 161 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5G 1L7, Ontario, Canada.
- 162 The University of Texas School of Public Health, Houston, 77030, Texas, USA.
- 163 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, 91010, California, USA.
- 164 Department of Medicine and Genetics, University of California, San Francisco, 94143, California, USA.
- 165 Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
- 166 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
- 167 Department of Molecular Genetics, National Institute of Oncology, Budapest, 1122, Hungary.
- 168 Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, 60637, Illinois, USA.
- 169 The Ohio State University and the James Cancer Center, Columbus, 43210, Ohio, USA.
- 170 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10017, USA.
- 171 Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, 28019, Spain.
- 172 Biomedical Network on Rare Diseases (CIBERER), Madrid, 28029, Spain.
- 173 Department of Surgery, Seoul National University College of Medicine, Seoul, 03080, Korea.
- 174 Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, 97239, Oregon, USA.
- 175 Knight Cancer Institute, Oregon Health and Science University, Portland, 97239, Oregon, USA.
- 176 IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, 16 20139, Italy.
- 177 Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria.
- 178 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, 33606, Florida, USA.
- 179 Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
- 180 Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, 02115, Massachusetts, USA.
- 181 Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, Oulu, FI-90014, Finland.
- 182 Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumour Biology, University of Oulu, Oulu, FI-90014, Finland.
- 183 Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, 20133, Italy.
- 184 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, 171 76, Sweden.
- 185 Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, 54000, Pakistan.
- 186 Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, 34362, Israel.
- 187 Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, 50931, Germany.
- 188 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, Connecticut, USA.
- 189 Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, 60201, Illinois, USA.
- 190 Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, USA.
- 191 Department of Epidemiology, University of Washington, Seattle, 98109, Washington, USA.
- 192 National Cancer Institute, Bangkok, 10400, Thailand.
- 193 Research Oncology, Guy's Hospital, King's College London, London, SE1 9RT, UK.
- 194 Department of Community and Family Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA.
- 195 Cancer Control and Population Sciences, Duke Cancer Institute, Durham, 27710, North Carolina, USA.
- 196 Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.
- 197 Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, 50676, Germany.
- 198 Center for Integrated Oncology, University Hospital of Cologne, Cologne, 50676, Germany.
- 199 Center for Molecular Medicine, University Hospital of Cologne, Cologne, 50676, Germany.
- 200 Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, 50676, Germany.
- 201 Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
- 202 School of Public Health, China Medical University, Taichung, 404, Taiwan.
- 203 Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, 94305, California, USA.
- 204 Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, 69008, France.
- 205 INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, 69003, France.
- 206 Department of Pathology, University of Melbourne, Parkville, 3010, Victoria, Australia.
- 207 Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, 581 83, Sweden.
- 208 Institut Curie, Department of Tumour Biology, Paris, France; Department of Tumour Biology, Institut Curie, Paris, France.
- 209 Institut Curie, INSERM U830, Paris, 75248, France.
- 210 Université Paris Descartes, Sorbonne Paris Cité, Paris, 75270, France.
- 211 Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, 69120, Germany.
- 212 Department of Genetics, Portuguese Oncology Institute, Porto, 4200-072, Portugal.
- 213 Biomedical Sciences Institute (ICBAS), Porto University, Porto, 4099-002, Portugal.
- 214 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10027, USA.
- 215 Department of Clinical Genetics, Odense University Hospital, Odense C, 5000, Denmark.
- 216 UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, 21100, Italy.
- 217 Latvian Biomedical Research and Study Centre, Riga, LV-1067, Latvia, Sweden.
- 218 Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Padua, 64 - 35128, Italy.
- 219 Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, Ohio, USA.
- 220 Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.
- 221 Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62, Bogota, Colombia.
- 222 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, 02215, Massachusetts, USA.
- 223 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
- 224 Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015 CE, The Netherlands.
- 225 Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, B-3000, Belgium.
- 226 University Hospital Ulm, Ulm, 89069, Germany.
- 227 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, Maryland, USA.
- 228 Department of General Medical Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, B-3000, Belgium.
- 229 Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens, 153 10, Greece.
- 230 Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500, Malaysia.
- 231 University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, 59100, Malaysia.
- 232 Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.
- 233 Shanghai Center for Disease Control and Prevention, Shanghai, China.
- 234 Division of Population Sciences, Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, 33612, Florida, USA.
- 235 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, Minnesota, USA.
- 236 Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK. aca20@medschl.cam.ac.uk.
- 237 The Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
# Contributed equally.
- PMID: 40925936
- PMCID: PMC12420822
- DOI: 10.1038/s41467-025-63507-x
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Published Erratum
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Kate Lawrenson et al.
Nat Commun.
.
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doi: 10.1038/s41467-025-63507-x.
Authors
Kate Lawrenson #
1
2
, Siddhartha Kar #
3
, Karen McCue
4
, Karoline Kuchenbaeker
5
, Kyriaki Michailidou
5
, Jonathan Tyrer
3
, Jonathan Beesley
4
, Susan J Ramus
1
, Qiyuan Li
6
7
, Melissa K Delgado
1
, Janet M Lee
1
, Kristiina Aittomäki
8
, Irene L Andrulis
9
10
, Hoda Anton-Culver
11
, Volker Arndt
12
, Banu K Arun
13
, Brita Arver
14
, Elisa V Bandera
15
, Monica Barile
16
, Rosa B Barkardottir
17
, Daniel Barrowdale
5
, Matthias W Beckmann
18
, Javier Benitez
19
20
, Andrew Berchuck
21
, Maria Bisogna
22
, Line Bjorge
23
24
, Carl Blomqvist
25
, William Blot
26
27
, Natalia Bogdanova
28
, Anders Bojesen
29
, Stig E Bojesen
30
31
32
, Manjeet K Bolla
5
, Bernardo Bonanni
16
, Anne-Lise Børresen-Dale
33
34
, Hiltrud Brauch
35
36
37
, Paul Brennan
38
, Hermann Brenner
12
37
39
, Fiona Bruinsma
40
, Joan Brunet
41
, Shaik Ahmad Buhari
42
, Barbara Burwinkel
43
44
, Ralf Butzow
45
46
, Saundra S Buys
47
, Qiuyin Cai
26
, Trinidad Caldes
48
, Ian Campbell
49
, Rikki Cannioto
50
, Jenny Chang-Claude
51
52
, Jocelyne Chiquette
53
, Ji-Yeob Choi
54
55
, Kathleen B M Claes
56
; GEMO Study Collaborators; Linda S Cook
57
, Angela Cox
58
, Daniel W Cramer
59
60
, Simon S Cross
61
, Cezary Cybulski
62
, Kamila Czene
63
, Mary B Daly
64
, Francesca Damiola
65
, Agnieszka Dansonka-Mieszkowska
66
, Hatef Darabi
63
, Joe Dennis
5
, Peter Devilee
67
68
, Orland Diez
69
, Jennifer A Doherty
70
, Susan M Domchek
71
, Cecilia M Dorfling
72
, Thilo Dörk
28
, Martine Dumont
73
, Hans Ehrencrona
74
75
, Bent Ejlertsen
76
, Steve Ellis
5
; EMBRACE; Christoph Engel
77
, Eunjung Lee
1
, D Gareth Evans
78
, Peter A Fasching
18
79
, Lidia Feliubadalo
80
, Jonine Figueroa
81
, Dieter Flesch-Janys
82
83
, Olivia Fletcher
84
85
, Henrik Flyger
86
, Lenka Foretova
87
, Florentia Fostira
88
, William D Foulkes
89
, Brooke L Fridley
90
, Eitan Friedman
91
, Debra Frost
5
, Gaetana Gambino
92
, Patricia A Ganz
93
, Judy Garber
94
, Montserrat García-Closas
81
95
, Aleksandra Gentry-Maharaj
96
, Maya Ghoussaini
3
, Graham G Giles
40
97
, Rosalind Glasspool
98
, Andrew K Godwin
99
, Mark S Goldberg
100
101
, David E Goldgar
102
, Anna González-Neira
19
, Ellen L Goode
103
, Marc T Goodman
104
105
, Mark H Greene
106
, Jacek Gronwald
107
, Pascal Guénel
108
109
, Christopher A Haiman
1
, Per Hall
63
, Emily Hallberg
103
, Ute Hamann
110
, Thomas V O Hansen
111
, Patricia A Harrington
112
, Mikael Hartman
42
113
, Norhashimah Hassan
114
115
, Sue Healey
4
; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Florian Heitz
116
117
, Josef Herzog
118
, Estrid Høgdall
119
120
, Claus K Høgdall
121
, Frans B L Hogervorst
122
, Antoinette Hollestelle
123
, John L Hopper
97
, Peter J Hulick
124
, Tomasz Huzarski
62
, Evgeny N Imyanitov
125
; KConFab Investigators; Australian Ovarian Cancer Study Group; Claudine Isaacs
126
, Hidemi Ito
127
, Anna Jakubowska
62
, Ramunas Janavicius
128
, Allan Jensen
121
, Esther M John
129
, Nichola Johnson
84
85
, Maria Kabisch
110
, Daehee Kang
54
55
130
, Miroslav Kapuscinski
131
, Beth Y Karlan
132
, Sofia Khan
45
, Lambertus A Kiemeney
133
, Susanne Kruger Kjaer
120
121
, Julia A Knight
134
135
, Irene Konstantopoulou
88
, Veli-Matti Kosma
136
137
138
, Vessela Kristensen
33
34
139
, Jolanta Kupryjanczyk
66
, Ava Kwong
140
141
, Miguel de la Hoya
48
, Yael Laitman
91
, Diether Lambrechts
142
143
, Nhu Le
1
, Kim De Leeneer
56
, Jenny Lester
132
, Douglas A Levine
22
, Jingmei Li
63
, Annika Lindblom
144
, Jirong Long
26
, Artitaya Lophatananon
145
, Jennifer T Loud
106
, Karen Lu
146
, Jan Lubinski
62
, Arto Mannermaa
136
137
138
, Siranoush Manoukian
147
, Loic Le Marchand
148
, Sara Margolin
149
, Frederik Marme
44
150
, Leon F A G Massuger
151
, Keitaro Matsuo
152
, Sylvie Mazoyer
65
, Lesley McGuffog
5
, Catriona McLean
153
, Iain McNeish
154
, Alfons Meindl
155
, Usha Menon
96
, Arjen R Mensenkamp
156
, Roger L Milne
40
97
, Marco Montagna
157
, Kirsten B Moysich
158
, Kenneth Muir
145
159
, Anna Marie Mulligan
160
161
, Katherine L Nathanson
71
, Roberta B Ness
162
, Susan L Neuhausen
163
, Heli Nevanlinna
45
, Silje Nord
34
, Robert L Nussbaum
164
, Kunle Odunsi
165
, Kenneth Offit
166
, Edith Olah
167
, Olufunmilayo I Olopade
168
, Janet E Olson
103
, Curtis Olswold
103
, David O'Malley
169
, Irene Orlow
170
, Nick Orr
84
, Ana Osorio
171
172
, Sue Kyung Park
55
130
173
, Celeste L Pearce
1
, Tanja Pejovic
174
175
, Paolo Peterlongo
176
, Georg Pfeiler
177
, Catherine M Phelan
178
, Elizabeth M Poole
179
180
, Katri Pylkäs
181
182
, Paolo Radice
183
, Johanna Rantala
184
, Muhammad Usman Rashid
110
185
, Gad Rennert
186
, Valerie Rhenius
3
, Kerstin Rhiem
187
, Harvey A Risch
188
, Gus Rodriguez
189
, Mary Anne Rossing
190
191
, Anja Rudolph
51
, Helga B Salvesen
23
24
, Suleeporn Sangrajrang
192
, Elinor J Sawyer
193
, Joellen M Schildkraut
194
195
, Marjanka K Schmidt
196
, Rita K Schmutzler
197
198
199
200
, Thomas A Sellers
178
, Caroline Seynaeve
123
, Mitul Shah
3
, Chen-Yang Shen
201
202
, Xiao-Ou Shu
26
, Weiva Sieh
203
, Christian F Singer
177
, Olga M Sinilnikova
204
205
, Susan Slager
103
, Honglin Song
3
, Penny Soucy
73
, Melissa C Southey
206
, Marie Stenmark-Askmalm
75
207
, Dominique Stoppa-Lyonnet
208
209
210
, Christian Sutter
211
, Anthony Swerdlow
85
95
, Sandrine Tchatchou
9
, Manuel R Teixeira
212
213
, Soo H Teo
114
115
, Kathryn L Terry
59
60
, Mary Beth Terry
214
, Mads Thomassen
215
, Maria Grazia Tibiletti
216
, Laima Tihomirova
217
, Silvia Tognazzo
218
, Amanda Ewart Toland
219
, Ian Tomlinson
220
, Diana Torres
110
221
, Thérèse Truong
108
109
, Chiu-Chen Tseng
1
, Nadine Tung
222
, Shelley S Tworoger
179
180
, Celine Vachon
103
, Ans M W van den Ouweland
223
, Helena C van Doorn
224
, Elizabeth J van Rensburg
72
, Laura J Van't Veer
196
, Adriaan Vanderstichele
225
, Ignace Vergote
225
, Joseph Vijai
166
, Qin Wang
5
, Shan Wang-Gohrke
226
, Jeffrey N Weitzel
118
, Nicolas Wentzensen
227
, Alice S Whittemore
203
, Hans Wildiers
228
, Robert Winqvist
181
182
, Anna H Wu
1
, Drakoulis Yannoukakos
229
, Sook-Yee Yoon
230
231
, Jyh-Cherng Yu
232
, Wei Zheng
26
, Ying Zheng
233
, Kum Kum Khanna
4
, Jacques Simard
73
, Alvaro N Monteiro
234
, Juliet D French
4
, Fergus J Couch
103
235
, Matthew L Freedman
7
, Douglas F Easton
3
5
, Alison M Dunning
3
, Paul D Pharoah
3
, Stacey L Edwards
4
, Georgia Chenevix-Trench
4
, Antonis C Antoniou
236
, Simon A Gayther
1
237
Collaborators
-
GEMO Study Collaborators:
Marie-Agnès Collonge-Rame, Alexandre Damette, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy, Pascaline Berthet, Dominique Vaur, Laurent Castera, Sandra Fert Ferrer, Yves-Jean Bignon, Nancy Uhrhammer, Fanny Coron, Laurence Faivre, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Sarab Lizard, Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon, Jean-Philippe Peyrat, Joëlle Fournier, Françoise Révillion, Claude Adenis, Laurence Vénat-Bouvet, Mélanie Léone, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Carole Verny-Pierre, Christine Lasset, Valérie Bonadona, Laure Barjhoux, Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, Isabelle Coupier, Pascal Pujol, Johanna Sokolowska, Myriam Bronner, Capucine Delnatte, Stéphane Bézieau, Véronique Mari, Marion Gauthier-Villars, Bruno Buecher, Etienne Rouleau, Lisa Golmard, Virginie Moncoutier, Muriel Belotti, Antoine de Pauw, Camille Elan, Emmanuelle Fourme, Anne-Marie Birot, Claire Saule, Maïté Laurent, Claude Houdayer, Fabienne Lesueur, Noura Mebirouk, Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin, Fabienne Prieur, Marine Lebrun, Caroline Kientz, Danièle Muller, Jean-Pierre Fricker, Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel, Isabelle Mortemousque, Brigitte Bressac-de-Paillerets, Olivier Caron, Marine Guillaud-Bataille
- EMBRACE:
-
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON):
M A Rookus, F E van Leeuwen, L E van der Kolk, M K Schmidt, N S Russell, J L de Lange, R Wijnands, J M Collée, M J Hooning, C Seynaeve, C H M van Deurzen, I M Obdeijn, C J van Asperen, R A E M Tollenaar, T C T E F van Cronenburg, C M Kets, M G E M Ausems, C C van der Pol, T A M van Os, Q Waisfisz, H E J Meijers-Heijboer, E B Gómez-Garcia, J C Oosterwijk, M J Mourits, G H de Bock, H F Vasen, S Siesling, J Verloop, L I H Overbeek
- KConFab Investigators:
- Australian Ovarian Cancer Study Group:
Affiliations
- 1 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
- 2 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 3 Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
- 4 QIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
- 5 Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
- 6 Medical College, Xiamen University, Xiamen, 361102, China.
- 7 Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
- 8 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, 00029 HUS, Finland.
- 9 Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
- 10 Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada.
- 11 Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, 92697, California, USA.
- 12 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 13 University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
- 14 Department of Oncology, Karolinska University Hospital, Stockholm, 171 77, Sweden.
- 15 Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, 08903, New Jersey, USA.
- 16 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, 20141, Italy.
- 17 Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, 600169-2039, Iceland.
- 18 Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, 91054, Germany.
- 19 Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, E-28029, Spain.
- 20 Centro de Investigación en Red de Enfermedades Raras, Valencia, 28029, Spain.
- 21 Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, North Carolina, USA.
- 22 Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
- 23 Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
- 24 Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, N-5020, Norway.
- 25 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, FIN-00029, Finland.
- 26 Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
- 27 International Epidemiology Institute, Rockville, 20850, Maryland, USA.
- 28 Gynaecology Research Unit, Hannover Medical School, Hannover, D-30625, Germany.
- 29 Department of Clinical Genetics, Vejle Hospital, Vejle, 7100, Denmark.
- 30 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
- 31 Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 32 Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 33 Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, N-0310, Norway.
- 34 K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, N-0310, Norway.
- 35 Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, D-70376, Germany.
- 36 University of Tübingen, Tübingen, 72074, Germany.
- 37 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 38 International Agency for Research on Cancer, Lyon, 69008, France.
- 39 Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
- 40 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Victoria, Australia.
- 41 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, 08908, Spain.
- 42 Department of Surgery, National University Health System, Singapore, 119077, Singapore.
- 43 Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 44 Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
- 45 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
- 46 Department of Pathology, Helsinki University Central Hospital, Helsinki, 00029, Finland.
- 47 Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84112, Utah, USA.
- 48 Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, 28040, Spain.
- 49 Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, 3002, Victoria, Australia.
- 50 Division of Cancer Prevention and Population Sciences, Cancer Pathology & Prevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, 14263, New York, USA.
- 51 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
- 52 University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 53 Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Québec City, G1J 1Z4, Québec, Canada.
- 54 Cancer Research Institute, Seoul National University, Seoul, 08826, Korea.
- 55 Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
- 56 Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.
- 57 Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, 87131, New Mexico, USA.
- 58 Department of Oncology, Sheffield Cancer Research, University of Sheffield, Sheffield, S10 2TN, UK.
- 59 Harvard HT Chan School of Public Health, Boston, 02115, Massachusetts, USA.
- 60 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
- 61 Department of Neuroscience, Academic Unit of Pathology, University of Sheffield, Sheffield, S10 2TN, UK.
- 62 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
- 63 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 64 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, 19111, Pennsylvania, USA.
- 65 INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, 69373, France.
- 66 Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, 44-101, Poland.
- 67 Department of Pathology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
- 68 Department of Human Genetics, Leiden University Medical Center, Leiden, 2333, The Netherlands.
- 69 Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, 08035, Spain.
- 70 Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, 03755, New Hampshire, USA.
- 71 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA.
- 72 Department of Genetics, University of Pretoria, Pretoria, 0083, South Africa.
- 73 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, G1V 4G2, Québec, Canada.
- 74 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 751 05, Sweden.
- 75 Department of Clinical Genetics, Lund University Hospital, Lund, 221 00, Sweden.
- 76 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
- 77 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, 04107, Germany.
- 78 Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9PL, UK.
- 79 Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, 90095, California, USA.
- 80 Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, Barcelona, 08908, Spain.
- 81 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, 20892, Maryland, USA.
- 82 Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 83 Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
- 84 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
- 85 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
- 86 Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
- 87 Masaryk Memorial Cancer Institute and Medical Faculty MU, Brno, 625 00, Czech Republic.
- 88 Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, 153 10, Greece.
- 89 Departments of Human Genetics and Oncology, Program in Cancer Genetics, McGill University, Montreal, Montreal, H2W 1S6, Quebec, Canada.
- 90 Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
- 91 Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, 52621, Israel.
- 92 Department of Laboratory Medicine, Section of Genetic Oncology, University and University Hospital of Pisa, Pisa, 56126, Italy.
- 93 Division of Cancer Prevention & Control Research, UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, 90024, California, USA.
- 94 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
- 95 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
- 96 Women's Cancer, UCL EGA Institute for Women's Health, London, WC1E 6AU, UK.
- 97 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Victoria, Australia.
- 98 Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK.
- 99 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
- 100 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, H3A 1A1, Québec, Canada.
- 101 Department of Medicine, McGill University, Montreal, H3A 1A1, Québec, Canada.
- 102 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84132, Utah, USA.
- 103 Department of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
- 104 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 105 Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 106 Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, 20892, Maryland, USA.
- 107 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-204, Poland.
- 108 Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, 94805, France.
- 109 University Paris-Sud, Villejuif, 91405, France.
- 110 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
- 111 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
- 112 Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
- 113 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 119077, Singapore.
- 114 Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, 50603, Malaysia.
- 115 Cancer Research Initiatives Foundation, Subang Jaya, Selangor, 47500, Malaysia.
- 116 Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, 45136, Germany.
- 117 Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, Wiesbaden, 65199, Germany.
- 118 Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, 91010, California, USA.
- 119 Department of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen, Copenhagen, 2730, Denmark.
- 120 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, DK-2100, Denmark.
- 121 Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark.
- 122 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, 1006, The Netherlands.
- 123 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015, The Netherlands.
- 124 Center for Medical Genetics, NorthShore University Health System, Evanston, 60201, Illinois, USA.
- 125 N.N. Petrov Institute of Oncology, St Petersburg, 197758, Russia.
- 126 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, 20057, District of Columbia, USA.
- 127 Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, 464-8681, Japan.
- 128 State Research Institute Centre for Innovative Medicine, Vilnius, LT-01102, Lithuania.
- 129 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, 94538, California, USA.
- 130 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 08826, Korea.
- 131 Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, 3010, Victoria, Australia.
- 132 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
- 133 Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, 6500, The Netherlands.
- 134 Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
- 135 Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, M5T 3M7, Ontario, Canada.
- 136 Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, 70210, Finland.
- 137 Cancer Center, Kuopio University Hospital, Kuopio, 70210, Finland.
- 138 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
- 139 Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, 1478, Oslo, Norway.
- 140 The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China.
- 141 Department of Surgery, The University of Hong Kong, Hong Kong, China.
- 142 Vesalius Research Center, VIB, Leuven, 3000, Belgium.
- 143 Department of Oncology, Laboratory for Translational Genetics, University of Leuven, Leuven, 3000, Belgium.
- 144 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 145 Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, CV4 7AL, UK.
- 146 Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
- 147 Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, 20133, Italy.
- 148 University of Hawaii Cancer Center, Honolulu, 96813, Hawaii, USA.
- 149 Department of Oncology - Pathology, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
- 150 National Center for Tumour Diseases, University of Heidelberg, Heidelberg, 69117, Germany.
- 151 Department of Gynaecology, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
- 152 Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, 812-8582, Japan.
- 153 Anatomical Pathology, The Alfred Hospital, Melbourne, 3004, Victoria, Australia.
- 154 Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK.
- 155 Division of Gynaecology and Obstetrics, Technische Universität München, Munich, 81675, Germany.
- 156 Department of Human Genetics, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
- 157 Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS, Padua, 35128, Italy.
- 158 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
- 159 Institute of Population Health, University of Manchester, Manchester, M13 9PL, UK.
- 160 Laboratory Medicine Program, University Health Network, Toronto, M5G 1L7, Ontario, Canada.
- 161 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5G 1L7, Ontario, Canada.
- 162 The University of Texas School of Public Health, Houston, 77030, Texas, USA.
- 163 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, 91010, California, USA.
- 164 Department of Medicine and Genetics, University of California, San Francisco, 94143, California, USA.
- 165 Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
- 166 Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
- 167 Department of Molecular Genetics, National Institute of Oncology, Budapest, 1122, Hungary.
- 168 Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, 60637, Illinois, USA.
- 169 The Ohio State University and the James Cancer Center, Columbus, 43210, Ohio, USA.
- 170 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10017, USA.
- 171 Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, 28019, Spain.
- 172 Biomedical Network on Rare Diseases (CIBERER), Madrid, 28029, Spain.
- 173 Department of Surgery, Seoul National University College of Medicine, Seoul, 03080, Korea.
- 174 Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, 97239, Oregon, USA.
- 175 Knight Cancer Institute, Oregon Health and Science University, Portland, 97239, Oregon, USA.
- 176 IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, 16 20139, Italy.
- 177 Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria.
- 178 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, 33606, Florida, USA.
- 179 Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
- 180 Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, 02115, Massachusetts, USA.
- 181 Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, Oulu, FI-90014, Finland.
- 182 Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumour Biology, University of Oulu, Oulu, FI-90014, Finland.
- 183 Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, 20133, Italy.
- 184 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, 171 76, Sweden.
- 185 Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, 54000, Pakistan.
- 186 Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, 34362, Israel.
- 187 Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, 50931, Germany.
- 188 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, Connecticut, USA.
- 189 Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, 60201, Illinois, USA.
- 190 Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, USA.
- 191 Department of Epidemiology, University of Washington, Seattle, 98109, Washington, USA.
- 192 National Cancer Institute, Bangkok, 10400, Thailand.
- 193 Research Oncology, Guy's Hospital, King's College London, London, SE1 9RT, UK.
- 194 Department of Community and Family Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA.
- 195 Cancer Control and Population Sciences, Duke Cancer Institute, Durham, 27710, North Carolina, USA.
- 196 Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.
- 197 Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, 50676, Germany.
- 198 Center for Integrated Oncology, University Hospital of Cologne, Cologne, 50676, Germany.
- 199 Center for Molecular Medicine, University Hospital of Cologne, Cologne, 50676, Germany.
- 200 Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, 50676, Germany.
- 201 Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
- 202 School of Public Health, China Medical University, Taichung, 404, Taiwan.
- 203 Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, 94305, California, USA.
- 204 Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, 69008, France.
- 205 INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, 69003, France.
- 206 Department of Pathology, University of Melbourne, Parkville, 3010, Victoria, Australia.
- 207 Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, 581 83, Sweden.
- 208 Institut Curie, Department of Tumour Biology, Paris, France; Department of Tumour Biology, Institut Curie, Paris, France.
- 209 Institut Curie, INSERM U830, Paris, 75248, France.
- 210 Université Paris Descartes, Sorbonne Paris Cité, Paris, 75270, France.
- 211 Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, 69120, Germany.
- 212 Department of Genetics, Portuguese Oncology Institute, Porto, 4200-072, Portugal.
- 213 Biomedical Sciences Institute (ICBAS), Porto University, Porto, 4099-002, Portugal.
- 214 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10027, USA.
- 215 Department of Clinical Genetics, Odense University Hospital, Odense C, 5000, Denmark.
- 216 UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, 21100, Italy.
- 217 Latvian Biomedical Research and Study Centre, Riga, LV-1067, Latvia, Sweden.
- 218 Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Padua, 64 - 35128, Italy.
- 219 Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, Ohio, USA.
- 220 Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.
- 221 Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62, Bogota, Colombia.
- 222 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, 02215, Massachusetts, USA.
- 223 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
- 224 Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015 CE, The Netherlands.
- 225 Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, B-3000, Belgium.
- 226 University Hospital Ulm, Ulm, 89069, Germany.
- 227 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, Maryland, USA.
- 228 Department of General Medical Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, B-3000, Belgium.
- 229 Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens, 153 10, Greece.
- 230 Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500, Malaysia.
- 231 University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, 59100, Malaysia.
- 232 Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.
- 233 Shanghai Center for Disease Control and Prevention, Shanghai, China.
- 234 Division of Population Sciences, Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, 33612, Florida, USA.
- 235 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 55905, Minnesota, USA.
- 236 Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK. aca20@medschl.cam.ac.uk.
- 237 The Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
# Contributed equally.
- PMID: 40925936
- PMCID: PMC12420822
- DOI: 10.1038/s41467-025-63507-x
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Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB, Barrowdale D, Beckmann MW, Benitez J, Berchuck A, Bisogna M, Bjorge L, Blomqvist C, Blot W, Bogdanova N, Bojesen A, Bojesen SE, Bolla MK, Bonanni B, Børresen-Dale AL, Brauch H, Brennan P, Brenner H, Bruinsma F, Brunet J, Buhari SA, Burwinkel B, Butzow R, Buys SS, Cai Q, Caldes T, Campbell I, Canniotto R, Chang-Claude J, Chiquette J, Choi JY, Claes KB; GEMO Study Collaborators; Cook LS, Cox A, Cramer DW, Cross SS, Cybulski C, Czene K, Daly MB, Damiola F, Dansonka-Mieszkowska A, Darabi H, Dennis J, Devilee P, Diez O, Doherty JA, Domchek SM, Dorfling CM, Dörk T, Dumont M, Ehrencrona H, Ejlertsen B, Ellis S; EMBRACE; Engel C, Lee E, Evans DG, Fasching PA, Feliubadalo L, Figueroa J, Flesch-Janys D, Fletcher O, Flyger H, Foretova L, Fostira F, Foulkes WD, Fridley BL, Friedman E, Frost D, Gambino G, Ganz PA, Garber J, García-Closas M, Gentry-Maharaj A, Ghoussaini M, Giles GG, Glasspool R, Godwin AK, Goldberg MS, Goldgar DE, González-Neira A, Goode EL, Goodman MT, Gree… See abstract for full author list ➔ Lawrenson K, et al. Nat Commun. 2016 Sep 7;7:12675. doi: 10.1038/ncomms12675. Nat Commun. 2016. PMID: 27601076 Free PMC article. Clinical Trial.
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