Editorial for "Hemispheric Asymmetry of Neuromelanin-Iron Dysfunction in the Substantia Nigra: MRI-Based Evidence for Lateralized Motor Onset in Early-Stage Parkinson's Disease"

Martín Martínez^{1

2}, Mikel Ariz^{3

4}, Ignacio Alvarez⁵, Tomás Muñoz Santoro³, Gabriel Castellanos⁶, Carlos Ortiz de Solórzano³, Pau Pastor^{5

7}, Maria A Pastor¹

Affiliations

¹ Neuroimaging Laboratory, School of Medicine, University of Navarra, Pamplona, Spain.
² Department of Psychology, School of Education and Psychology, University of Navarra, Pamplona, Spain.
³ Ciberonc and Solid Tumours and Biomarkers Program, CIMA University of Navarra, Pamplona, Spain.
⁴ Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain.
⁵ Neurosciences, the Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain.
⁶ Department of Physiological Sciences, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
⁷ Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol, Barcelona, Spain.

Editorial

Martín Martínez et al. J Magn Reson Imaging. 2025.

. 2025 Sep 10.

doi: 10.1002/jmri.70121. Online ahead of print.

Martín Martínez^{1

2}, Mikel Ariz^{3

4}, Ignacio Alvarez⁵, Tomás Muñoz Santoro³, Gabriel Castellanos⁶, Carlos Ortiz de Solórzano³, Pau Pastor^{5

7}, Maria A Pastor¹

¹ Neuroimaging Laboratory, School of Medicine, University of Navarra, Pamplona, Spain.
² Department of Psychology, School of Education and Psychology, University of Navarra, Pamplona, Spain.
³ Ciberonc and Solid Tumours and Biomarkers Program, CIMA University of Navarra, Pamplona, Spain.
⁴ Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain.
⁵ Neurosciences, the Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain.
⁶ Department of Physiological Sciences, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
⁷ Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol, Barcelona, Spain.

No abstract available

References

1. L. Zecca, R. Fariello, P. Riedererc, D. Sulzer, A. Gattia, and D. Tampellini, “The Absolute Concentration of Nigral Neuromelanin, Assayed by a New Sensitive Method, Increases Throughout the Life and Is Dramatically Decreased in Parkinson's Disease,” FEBS Letters 510 (2002): 216–220, https://doi.org/10.1016/s0014‐5793(01)03269‐0.
1. R. Djaldetti, I. Ziv, and E. Melamed, “The Mystery of Motor Asymmetry in Parkinson's Disease,” Lancet Neurology 5, no. 9 (2006): 796–802, https://doi.org/10.1016/S1474‐4422(06)70549‐X.
1. Y. Li, X.‐l. Liu, N. Wang, et al., “Hemispheric Asymmetry of Neuromelanin‐Iron Dysfunction in the Substantia Nigra: MRI‐Based Evidence for Lateralized Motor Onset in Early‐Stage Parkinson's Disease,” Journal of Magnetic Resonance Imaging 25 (2025): 1054, https://doi.org/10.1002/jmri.70110.
1. N. He, K. Ghassaban, P. Huang, et al., “Imaging Iron and Neuromelanin Simultaneously Using a Single 3D Gradient Echo Magnetization Transfer Sequence,” NeuroImage 230 (2021): 117810, https://doi.org/10.1016/j.neuroimage.2021.117810.
1. X. L. Liu, L. Q. Yang, F. T. Liu, et al., “Short‐Echo‐Time Magnitude Image Derived From Quantitative Susceptibility Mapping Could Resemble Neuromelanin‐Sensitive MRI Image in Substantia Nigra,” BMC Neurology 20, no. 1 (2020): 262, https://doi.org/10.1186/s12883‐020‐01828‐8.