Rhythm, Risk, and Responsibility: Assessing the Safety of Testosterone Replacement in Aging Men with Androgen Deficiency
- PMID: 40928714
- DOI: 10.1007/s40256-025-00763-8
Rhythm, Risk, and Responsibility: Assessing the Safety of Testosterone Replacement in Aging Men with Androgen Deficiency
Conflict of interest statement
Declarations. Funding: No external funding was used in the preparation of this Commentary. Conflict of interest: Caique M.P. Ternes declares no potential conflicts of interest that might be relevant to the contents of this Commentary. Data availability statement: Data sharing is not applicable to this Commentary, as no datasets were generated for it. Ethics approval: Not applicable. Code availability: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Author contributions: Caique M.P. Ternes is responsible for writing and editing this Commentary.
Comment on
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Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials.Am J Cardiovasc Drugs. 2025 Nov;25(6):767-777. doi: 10.1007/s40256-025-00737-w. Epub 2025 Jul 22. Am J Cardiovasc Drugs. 2025. PMID: 40694252
References
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- Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular safety of testosterone-replacement therapy. N Engl J Med. 2023;389(2):107–17. https://doi.org/10.1056/NEJMoa2215025 . - DOI - PubMed
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- Wittert G, Bracken K, Robledo KP, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021;9(1):32–45. https://doi.org/10.1016/S2213-8587(20)30367-3 . - DOI - PubMed
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- Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611–24. https://doi.org/10.1056/NEJMoa1506119 . - DOI - PubMed - PMC
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