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. 1977 Sep;84(3):299-304.
doi: 10.1016/0002-9394(77)90668-7.

Experimental intraocular penetration of dacarbazine

Z M Wilczek

Experimental intraocular penetration of dacarbazine

Z M Wilczek. Am J Ophthalmol. 1977 Sep.

Abstract

Radioactive carbon (14C)-labeled dacarbazine was used to trace penetration of the drug to the eye after intravenous and subtenon-retrobulbar injection on experimental animals. After subtenonretrobulbar injection of 1 or 2.5 mg of commercial dacarbazine twice daily for two weeks, there were no clinical changes. However, doses of 5 to 7.5 mg per injection produced destructive chorioretinitis, and a proliferative type of retinopathy was confirmed histopathologically.

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