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Practice Guideline
. 2025 Sep;23(9):403-418.
doi: 10.6004/jnccn.2025.0042.

Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

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Practice Guideline

Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology

Al B Benson 3rd et al. J Natl Compr Canc Netw. 2025 Sep.

Abstract

The NCCN Guidelines for Biliary Tract Cancers (BTCs) provide recommendations for the evaluation and comprehensive care of patients with gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma. The multidisciplinary panel of experts is convened at least once annually to review requests from internal and external entities as well as to evaluate new data on current and emerging therapies. This manuscript focuses on the adjuvant chemotherapy and chemoradiation treatment options for BTCs as well as the systemic treatment recommendations for patients with advanced BTCs.

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