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Practice Guideline
. 2025 Sep;23(9):354-362.
doi: 10.6004/jnccn.2025.0043.

NCCN Guidelines® Insights: Non-Small Cell Lung Cancer, Version 7.2025

Gregory J Riely  1 , Douglas E Wood  2 , Dara L Aisner  3 , Billy W Loo Jr  4 , Andrea L Axtell  5 , Jessica R Bauman  6 , Ankit Bharat  7 , Joe Y Chang  8 , Aakash Desai  9 , Thomas J Dilling  10 , Jonathan Dowell  11 , Gregory A Durm  12 , Scott Gettinger  13 , Travis E Grotz  14 , Matthew A Gubens  15 , Aditya Juloori  16 , Rudy P Lackner  17 , Michael Lanuti  18 , Benjamin Levy  19 , Jules Lin  20 , Christine M Lovly  21 , Fabien Maldonado  21 , Daniel Morgensztern  22 , Trey C Mullikin  23 , Thomas Ng  24 , Dawn Owen  14 , Dwight H Owen  25 , Sandip P Patel  26 , Tejas Patil  3 , Patricio M Polanco  11 , Jonathan Riess  27 , Ana Lucia Ruano Mendez  28 , Theresa A Shapiro  19 , Aditi P Singh  29 , James Stevenson  30 , Alda Tam  8 , Tawee Tanvetyanon  10 , Jane Yanagawa  31 , Edwin Yau  32 , Kristina Gregory  33 , Lisa Hang  33
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Practice Guideline

NCCN Guidelines® Insights: Non-Small Cell Lung Cancer, Version 7.2025

Gregory J Riely et al. J Natl Compr Canc Netw. 2025 Sep.

Abstract

The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) provide recommendations for the treatment of NSCLC. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines, with a focus on systemic therapy options for the treatment of patients with nonmetastatic NSCLC and the corresponding molecular testing considerations.

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