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Review
. 2025 Sep 8;70(2):353-366.
doi: 10.1016/j.advms.2025.09.002. Online ahead of print.

Atherosclerosis in the context of hemostasis and neovascularization - Current state of knowledge

Affiliations
Review

Atherosclerosis in the context of hemostasis and neovascularization - Current state of knowledge

Urszula Jakobsche-Policht et al. Adv Med Sci. .

Abstract

Atherosclerosis is a progressive process resulting from endothelial dysfunction, primarily caused by damage to the integrity of the glycocalyx. Its pathogenesis is complex and involves numerous biomechanical and biochemical factors, such as blood pressure, shear forces, lipid metabolism disorders, monocyte migration and their transformation into macrophages, immune response, lipid accumulation, neovascularization, and activation of coagulation. Recently, the possibility of atherosclerosis regression has been confirmed, although the mechanisms behind the reversal of changes remain unknown. This review presents current knowledge on the pathogenesis of atherosclerosis, with particular emphasis on pro-atherogenic processes in the glycocalyx and endothelium, especially those related to hemostasis, neovascularization, and epigenetic changes.

Keywords: Atherosclerosis; Hemostasis; Neovascularization; Platelets; oxLDL.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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