Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Published Erratum
. 2025 Sep 10;15(1):32402.
doi: 10.1038/s41598-025-17199-4.

Author Correction: Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments

Azadeh Rezaei  1 , Yutong Li  1 , Mark Turmaine  2 , Sergio Bertazzo  3 , Christopher A Howard  4 , Timothy R Arnett  2 , Kaveh Shakib  5 , Gavin Jell  6
Affiliations
Published Erratum

Author Correction: Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments

Azadeh Rezaei et al. Sci Rep. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Hypoxia (1% O2) and hyperglycaemia inhibited bone nodule formation. After 21 days, Alizarin Red stained (ARS) dense nodules were observed in (a) normal (5.5 mM) glucose, whilst (b) moderate (25 mM) and (c) high (50 mM) glucose conditions inhibited nodule formation. (d) Hypoxia normal glucose showed discrete biomineralisation that was not associated with collagen fibres. (e) Moderate and (f) high glucose inhibited biomineralisation. Transmission electron microscopy (TEM) micrographs of (g) normoxia normal glucose, (h) moderate glucose and (i) high glucose showed a glucose concentration dependent inhibition of bone nodule formation. COL fibres were not observed in (j) hypoxia normal glucose, but (k) moderate and high glucose environments in hypoxia showed some collagen fibres. Scale bar for (a–f) is 200 µm and for (g–i) is 2 µm (n = 5) (N: nodule, COL: collagen fibres, OB: osteoblast).
Fig. 3
Fig. 3
CoCl2 and DMOG restored nodule formation in hyperglycaemic cultured osteoblasts. After 21 days, Alizarin Red staining (ARS) showed bone nodule formation in untreated cultures in (a) normal glucose (5.5 mM), whilst the addition of (b) moderate (25 mM) and (c) high glucose (50 mM) inhibited nodule formation. (d–o) Cultures treated with hypoxia mimetics CoCl2 and DMOG decreased bone nodule formation in normal glucose levels but increased bone nodule formation in moderate and high glucose levels compared to untreated controls. Scale bar for all images is 200 µm (n = 5).
See this image and copyright information in PMC

Erratum for

Publication types

LinkOut - more resources