Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response

Affiliations

¹ Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
² Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
³ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA.
⁴ The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY; Tri-Institutional Computational Biology and Medicine program, Weill Cornell Medicine, New York.
⁵ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York.
⁶ Multiparametric In Situ Imaging (MISI) Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York.
⁷ Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
⁸ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY; Tri-Institutional Computational Biology and Medicine program, Weill Cornell Medicine, New York, NY; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York.
⁹ Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, NY; Multiparametric In Situ Imaging (MISI) Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York. sap9151@med.cornell.edu.

PMID: 40931876
DOI: 10.3324/haematol.2025.288054

Free article

Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response

Paul D Barone et al. Haematologica. 2025.

Free article

. 2025 Sep 11.

doi: 10.3324/haematol.2025.288054. Online ahead of print.

Authors

Affiliations

¹ Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
² Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
³ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA.
⁴ The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY; Tri-Institutional Computational Biology and Medicine program, Weill Cornell Medicine, New York.
⁵ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York.
⁶ Multiparametric In Situ Imaging (MISI) Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York.
⁷ Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.
⁸ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY; Tri-Institutional Computational Biology and Medicine program, Weill Cornell Medicine, New York, NY; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York.
⁹ Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York, NY; Multiparametric In Situ Imaging (MISI) Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York. sap9151@med.cornell.edu.

PMID: 40931876
DOI: 10.3324/haematol.2025.288054

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Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response

Affiliations

Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response

Authors

Affiliations

Abstract

LinkOut - more resources

Full Text Sources