Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Sep 11;151(9):254.
doi: 10.1007/s00432-025-06305-8.

The role of the transcription factor PATZ1 in tumorigenesis and metabolic regulation

Yin Zheng  1 , Jiabo Chen  2 , Cheng Su  3
Affiliations
Review

The role of the transcription factor PATZ1 in tumorigenesis and metabolic regulation

Yin Zheng et al. J Cancer Res Clin Oncol. .

Abstract

PATZ1 (POZ/BTB and AT hook containing zinc finger 1) is an important member of the POZ/BTB (Poxvirus and Zinc finger / Broad-complex, Tramtrack, and Bric-à-brac) family and has been confirmed to be involved in the development and progression of various tumors. Moreover, differential expression of PATZ1 is associated with the prognosis of multiple cancers and systemic metabolic patterns. It participates in the regulation of oncogenes and a range of biological processes, including glucose and lipid metabolism. This review aims to summarize the current understanding of the relationship between the transcription factor PATZ1, tumorigenesis, and metabolism, with the goal of providing a theoretical basis for the development of PATZ1-targeted therapies.

Keywords: Metabolism; PATZ1; Tumor.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic structure of PATZ1
Fig. 2
Fig. 2
Metabolic Mechanisms Involving PATZ1
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Ahmadi SE, Rahimi S, Zarandi B, Chegeni R, Safa M (2021) MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies. J Hematol Oncol 14:121. 10.1186/s13045-021-01111-4 - PMC - PubMed
    1. Alhalabi KT, Stichel D, Sievers P et al (2021) PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol 142:841–857. 10.1007/s00401-021-02354-8 - PMC - PubMed
    1. Alsayed R, Sheikhan K, Alam MA, Buddenkotte J, Steinhoff M, Uddin S, Ahmad A (2023) Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions. Semin Cancer Biol 92:74–83. 10.1016/j.semcancer.2023.04.005 - PubMed
    1. Andersen L, Gülich AF, Alteneder M et al (2019) The transcription factor MAZR/PATZ1 regulates the development of FOXP3(+) regulatory T cells. Cell Rep 29:4447–4459e4446. 10.1016/j.celrep.2019.11.089 - PubMed
    1. Antonescu CR, Zhang L, Chang NE et al (2010) EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer 49:1114–1124. 10.1002/gcc.20819 - PMC - PubMed

LinkOut - more resources