Comment on

• The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma.

  Perini T, Zordan P, Del Pizzo R, Resnati M, Viviani L, Stefanoni D, Cassina L, Orfanelli U, Trudu M, Oliva L, Lacidogna D, Samur MK, Materozzi M, Drago D, Andolfo A, Patrone M, Degano M, Boletta A, Milan E, Ciceri F, Munshi NC, Bellone M, Cenci S. Perini T, et al. Blood. 2025 Sep 11;146(11):1286-1299. doi: 10.1182/blood.2024026340. Blood. 2025. PMID: 40300074