Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 5;7(3):164-168.
doi: 10.24875/RECICE.M25000510. eCollection 2025.

Transcatheter closure of multiperforated atrial septal defect

Luis Cerdán Ferreira  1 , Georgina Fuertes Ferre  1 , Juan Sánchez-Rubio Lezcano  1 , Marta López Ramón  1
Affiliations

Transcatheter closure of multiperforated atrial septal defect

Luis Cerdán Ferreira et al. REC Interv Cardiol. .

Abstract
in English, Spanish

Introduction and objectives: Multi-fenestrated atrial septal defects (mASD) pose both diagnostic and therapeutic challenges. This study aimed to compare the outcomes of transcatheter closure in patients with mASD vs those with a single ASD at our center.

Methods: We conducted a retrospective, single-center study including adult patients who underwent transcatheter ASD closure from October 2014 through October 2024. Demographic, echocardiographic, and hemodynamic data were collected, with a the 6-month follow-up.

Results: A total of 67 patients were included, 12 of whom (18%) exhibited mASD. Patients with mASD were younger (42 vs 54 years) and more frequently presented with an interatrial septal aneurysm (91% vs 27%; P = .001). The use of multiple occlusion devices was more common in patients with mASD (34% vs 4%; P = .008). Complications were rare (5.9%) and none occurred in the mASD group. Procedural outcomes, including residual shunt and right ventricular remodeling at the follow-up, were comparable between groups.

Conclusions: Transcatheter closure of mASD is both a safe and feasible procedure, with clinical outcomes similar to those observed in patients with a single ASD.

Introducción y objetivos: La comunicación interauricular (CIA) multiperforada (CIAm) supone un reto diagnóstico y terapéutico. En este estudio se comparan los resultados del cierre percutáneo en pacientes con CIAm y con CIA simple en nuestro centro.

Métodos: Estudio retrospectivo unicéntrico en pacientes adultos con CIA sometidos a cierre percutáneo entre octubre de 2014 y octubre de 2024. Se recopilaron datos demográficos, ecocardiográficos y hemodinámicos, con seguimiento a los 6 meses.

Resultados: Se incluyeron 67 pacientes, 12 de ellos con CIAm (18%). Los pacientes con CIAm eran más jóvenes (42 frente a 54 años) y presentaban con mayor frecuencia aneurisma del tabique interauricular (91 frente a 27%, p = 0,001). El uso de varios dispositivos fue más frecuente en la CIAm (34 frente a 4%, p = 0,008). Las complicaciones fueron raras (5,9%, ninguna de ellas en pacientes con CIAm). Los resultados del procedimiento (shunt residual, remodelado del ventrículo derecho) en el seguimiento fueron similares en ambos grupos.

Conclusiones: El cierre percutáneo de la CIAm es factible y seguro, con resultados similares a los observados en pacientes con CIA no multiperforada.

Keywords: Multi-fenestrated atrial septal defects; Ostium secundum atrial septal defects; Transcatheter closure.

PubMed Disclaimer

Conflict of interest statement

CONFLICTO DE INTERESES: Los autores no presentan conflictos de intereses.

Figures

Figure 1
Figure 1. A: fluoroscopic image of the closure of a multi-fenestrated atrial septal defect with 2 devices guided by fluoroscopy, transesophageal echocardiography, and intraconary ultrasound. B: transesophageal echocardiography, mid-esophageal plane, showing the 2 implanted closure devices.
Figura 1
Figura 1. A: imagen fluoroscópica del cierre de una comunicación interauricular multiperforada con 2 dispositivos guiado por fluoroscopia, ecocardiografía transesofágica y ecografía intracardiaca. B: ecocardiografía transesofágica, plano medio esofágico, que muestra los 2 dispositivos de cierre implantados.
See this image and copyright information in PMC

References

    1. Brida M, Chessa M, Celermajer D, et al. Atrial septal defect in adulthood:a new paradigm for congenital heart disease. Eur Heart J. 2022;43:2660-2671. - PubMed
    2. Brida M, Chessa M, Celermajer D, et al. Atrial septal defect in adulthood:a new paradigm for congenital heart disease. Eur Heart J. 2022;43:2660–2671. - PubMed
    1. Masseli J, Bertog S, Stanczak L, et al. Transcatheter closure of multiple interatrial communications. Catheter Cardiovasc Interv. 2013;81:825-836. - PubMed
    2. Masseli J, Bertog S, Stanczak L, et al. Transcatheter closure of multiple interatrial communications. Catheter Cardiovasc Interv. 2013;81:825–836. - PubMed
    1. Yang Y, Xu Z, Jiang S, et al. Simultaneous Transcatheter Closure of Multiple Atrial Septal Defects Using Dual Amplatzer Septal Occluder Devices. Am J Med Sci. 2016;352:245-251. - PubMed
    2. Yang Y, Xu Z, Jiang S, et al. Simultaneous Transcatheter Closure of Multiple Atrial Septal Defects Using Dual Amplatzer Septal Occluder Devices. Am J Med Sci. 2016;352:245–251. - PubMed
    1. Butera G, Romagnoli E, Saliba Z, et al. Percutaneous closure of multiple defects of the atrial septum:procedural results and long-term follow-up. Catheter Cardiovasc Interv. 2010;76:121-128. - PubMed
    2. Butera G, Romagnoli E, Saliba Z, et al. Percutaneous closure of multiple defects of the atrial septum:procedural results and long-term follow-up. Catheter Cardiovasc Interv. 2010;76:121–128. - PubMed
    1. Silvestry FE, Cohen MS, Armsby LB, et al. Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale:From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions. J Am Soc Echocardiogr. 2015;28:910-958. - PubMed
    2. Silvestry FE, Cohen MS, Armsby LB, et al. Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale:From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions. J Am Soc Echocardiogr. 2015;28:910–958. - PubMed

LinkOut - more resources