doi: 10.7164/antibiotics.38.1670.
A novel macromolecular antibiotic, SN-07. Taxonomy of producing organism, isolation, characterization and biological activities
- PMID: 4093331
- DOI: 10.7164/antibiotics.38.1670
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A novel macromolecular antibiotic, SN-07. Taxonomy of producing organism, isolation, characterization and biological activities
J Antibiot (Tokyo).
1985 Dec.
Free article
Abstract
A novel macromolecular antibiotic SN-07 was obtained from the cultural supernatant of Actinomadura roseoviolacea var. miuraensis nov. var. The antibiotic was soluble in water, had a molecular weight of 18,000-22,000 daltons in 50 mM Tris-HCl buffer, pH 7.0, containing 2.0 M KCl as compared with authentic proteins. Its major constituents were nucleic acids. The substance had antibacterial activity against Gram-positive bacteria. It was also effective against lymphocytic leukemia P388 in vivo.
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