Biomarkers of ageing of humans and non-human primates

Zeming Wu^{1

2}, Jing Qu^{3

4

5

6}, Weiqi Zhang^{7

8

9}; Aging Biomarker Consortium; Guang-Hui Liu^{10

11

12

13}

Collaborators, Affiliations

Collaborators

Aging Biomarker Consortium:
Zhijun Bao, Yan Bi, Jian-Ping Cai, Shi-Qing Cai, Chun-Mei Cao, Feng Cao, Zhongwei Cao, Renjie Chai, Piu Chan, Chang Chen, Di Chen, Fangyi Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Lin Chen, Xiaochun Chen, Zheng Chen, Weimin Ci, Zhe Dai, Lianfu Deng, Bi-Sen Ding, Qiurong Ding, Birong Dong, Biao Dong, Yaodong Dong, Jian-Gao Fan, Qiaojun Fang, Shiqing Feng, Yun Feng, Xiaolong Fu, Zhenji Gan, Feng Gao, Jiangang Gao, Qiang Gao, Shaorong Gao, Xia Gao, Xiang Gao, Shusheng Gong, Yonghao Gu, Youfei Guan, Feifan Guo, Qihao Guo, Jing-Dong J Han, Haiping Hao, Jinhan He, Mingguang He, Qiyang He, Zhiying He, Zuhong He, Huashan Hong, Jiaxu Hong, Shengping Hou, Yunlong Hou, Cheng Hu, Ping Hu, Kai Huang, Pengyu Huang, Mengmeng Jiang, Zi-Bing Jin, Kangxin Jin, Lingjing Jin, Zhenyu Ju, Qing-Peng Kong, Wei-Jia Kong, Xiangqing Kong, Guanghua Lei, Jian Li, Geng-Lin Li, Huawei Li, Ji Li, Jingyi Li, Peng Li, Wenyan Li, Xiao-Jun Li, Xin Li, Yun Li, Zijian Li, Qingfeng Liang, Zhen Liang, Baohua Liu, Feng Liu, Guang-Hui Liu, Jun-Ping Liu, Lin Liu, Peng Liu, Pingsheng Liu, Qiang Liu, Qiang Liu, Wenwen Liu, Xingguo Liu, Yong Liu, Youshuo Liu, Yuhe Liu, Ke Liu, Xiao Long, Qian Lu, Yao Lu, Fan Lu, Jian Luo, Xianghang Luo, Shuai Ma, Xin Ma, Xinran Ma, Xiulan Ma, Zhiyong Mao, Shyh-Chang Ng, Gang Pei, Yaojin Peng, Jun Pu, Jieyu Qi, Xiaoyun Qian, Li Qiang, Yingying Qin, Jing Qu, Jie Ren, Ruibao Ren, Xiong Z Ruan, Tao Shen, Haibo Shi, Yilai Shu, Zhou Songyang, Chunli Song, Moshi Song, Weihong Song, Wenru Su, Aijun Sun, Jinpeng Sun, Liang Sun, Qiang Sun, Yi Eve Sun, Yu Sun, Yu Sun, Qi-Qun Tang, Tingting Tang, Peifu Tang, Yi Tang, Jun Tao, Ling Tao, Mei Tian, Xiao-Li Tian, Ye Tian, Zhao-Yang Wang, Liheng Wang, Cong-Yi Wang, Difei Wang, Haibo Wang, Hongyang Wang, Hua Wang, Huating Wang, Jiqiu Wang, Jianwei Wang, Li Wang, Lin Wang, Miao Wang, Peijun Wang, Shusen Wang, Si Wang, Wengong Wang, Xia Wang, Xiaoning Wang, Xiaoming Wang, Yan-Jiang Wang, Yuan Wang, Yunfang Wang, Xiaochun Wei, Lai Wei, Jianping Weng, Catherine C L Wong, Chengtie Wu, Jihong Wu, Zeming Wu, Xiaohuan Xia, Yang Xia, Andy Peng Xiang, Guozhi Xiao, Junjie Xiao, Qian Xiao, Yichuan Xiao, Zhi-Xiong Jim Xiao, Zhengwei Xie, Wei Xiong, Wei Xiong, Aimin Xu, Lei Xu, Lingyan Xu, Ming Xu, Zhigang Xu, Daichao Xu, Biao Yan, Jichun Yang, Liu Yang, Qi Yang, Tao Yang, Ze Yang, Jing Ye, Keqiang Ye, Chengqi Yi, Fan Yi, Yang Yu, Honghua Yu, Lisheng Yu, Wei Yu, Huijun Yuan, Wei Yuan, Jirong Yue, Rui Yue, Dingjun Zha, Cuntai Zhang, Hongbo Zhang, Huijie Zhang, Jingjing Zhang, Licheng Zhang, Qingjiong Zhang, Weiqi Zhang, Xinchao Zhang, Xuxiang Zhang, Yan Zhang, Yong Zhang, Yun-Wu Zhang, Zhanjun Zhang, Changqing Zhang, Zhuohua Zhang, Weiping J Zhang, Xiaoqing Zhang, Zhen-Lin Zhang, Jiajun Zhao, Tongbiao Zhao, Yuzheng Zhao, Jialin C Zheng, Zhuozhao Zheng, Zhongjun Zhou, Zhiming Zhu, Wenjuan Zhuang, Weiguo Zou

Affiliations

¹ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
² School of Life Sciences, Jilin University, Changchun, China.
³ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. qujing@ioz.ac.cn.
⁵ University of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
⁶ Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. qujing@ioz.ac.cn.
⁷ University of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
⁸ China National Center for Bioinformation, Beijing, China. zhangwq@big.ac.cn.
⁹ Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
¹⁰ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
¹¹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
¹² University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
¹³ National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.

PMID: 40935898
DOI: 10.1038/s41580-025-00883-8

Review

Biomarkers of ageing of humans and non-human primates

Zeming Wu et al. Nat Rev Mol Cell Biol. 2025.

. 2025 Sep 11.

doi: 10.1038/s41580-025-00883-8. Online ahead of print.

Authors

Zeming Wu^{1

2}, Jing Qu^{3

4

5

6}, Weiqi Zhang^{7

8

9}; Aging Biomarker Consortium; Guang-Hui Liu^{10

11

12

13}

Collaborators

Aging Biomarker Consortium:
Zhijun Bao, Yan Bi, Jian-Ping Cai, Shi-Qing Cai, Chun-Mei Cao, Feng Cao, Zhongwei Cao, Renjie Chai, Piu Chan, Chang Chen, Di Chen, Fangyi Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Lin Chen, Xiaochun Chen, Zheng Chen, Weimin Ci, Zhe Dai, Lianfu Deng, Bi-Sen Ding, Qiurong Ding, Birong Dong, Biao Dong, Yaodong Dong, Jian-Gao Fan, Qiaojun Fang, Shiqing Feng, Yun Feng, Xiaolong Fu, Zhenji Gan, Feng Gao, Jiangang Gao, Qiang Gao, Shaorong Gao, Xia Gao, Xiang Gao, Shusheng Gong, Yonghao Gu, Youfei Guan, Feifan Guo, Qihao Guo, Jing-Dong J Han, Haiping Hao, Jinhan He, Mingguang He, Qiyang He, Zhiying He, Zuhong He, Huashan Hong, Jiaxu Hong, Shengping Hou, Yunlong Hou, Cheng Hu, Ping Hu, Kai Huang, Pengyu Huang, Mengmeng Jiang, Zi-Bing Jin, Kangxin Jin, Lingjing Jin, Zhenyu Ju, Qing-Peng Kong, Wei-Jia Kong, Xiangqing Kong, Guanghua Lei, Jian Li, Geng-Lin Li, Huawei Li, Ji Li, Jingyi Li, Peng Li, Wenyan Li, Xiao-Jun Li, Xin Li, Yun Li, Zijian Li, Qingfeng Liang, Zhen Liang, Baohua Liu, Feng Liu, Guang-Hui Liu, Jun-Ping Liu, Lin Liu, Peng Liu, Pingsheng Liu, Qiang Liu, Qiang Liu, Wenwen Liu, Xingguo Liu, Yong Liu, Youshuo Liu, Yuhe Liu, Ke Liu, Xiao Long, Qian Lu, Yao Lu, Fan Lu, Jian Luo, Xianghang Luo, Shuai Ma, Xin Ma, Xinran Ma, Xiulan Ma, Zhiyong Mao, Shyh-Chang Ng, Gang Pei, Yaojin Peng, Jun Pu, Jieyu Qi, Xiaoyun Qian, Li Qiang, Yingying Qin, Jing Qu, Jie Ren, Ruibao Ren, Xiong Z Ruan, Tao Shen, Haibo Shi, Yilai Shu, Zhou Songyang, Chunli Song, Moshi Song, Weihong Song, Wenru Su, Aijun Sun, Jinpeng Sun, Liang Sun, Qiang Sun, Yi Eve Sun, Yu Sun, Yu Sun, Qi-Qun Tang, Tingting Tang, Peifu Tang, Yi Tang, Jun Tao, Ling Tao, Mei Tian, Xiao-Li Tian, Ye Tian, Zhao-Yang Wang, Liheng Wang, Cong-Yi Wang, Difei Wang, Haibo Wang, Hongyang Wang, Hua Wang, Huating Wang, Jiqiu Wang, Jianwei Wang, Li Wang, Lin Wang, Miao Wang, Peijun Wang, Shusen Wang, Si Wang, Wengong Wang, Xia Wang, Xiaoning Wang, Xiaoming Wang, Yan-Jiang Wang, Yuan Wang, Yunfang Wang, Xiaochun Wei, Lai Wei, Jianping Weng, Catherine C L Wong, Chengtie Wu, Jihong Wu, Zeming Wu, Xiaohuan Xia, Yang Xia, Andy Peng Xiang, Guozhi Xiao, Junjie Xiao, Qian Xiao, Yichuan Xiao, Zhi-Xiong Jim Xiao, Zhengwei Xie, Wei Xiong, Wei Xiong, Aimin Xu, Lei Xu, Lingyan Xu, Ming Xu, Zhigang Xu, Daichao Xu, Biao Yan, Jichun Yang, Liu Yang, Qi Yang, Tao Yang, Ze Yang, Jing Ye, Keqiang Ye, Chengqi Yi, Fan Yi, Yang Yu, Honghua Yu, Lisheng Yu, Wei Yu, Huijun Yuan, Wei Yuan, Jirong Yue, Rui Yue, Dingjun Zha, Cuntai Zhang, Hongbo Zhang, Huijie Zhang, Jingjing Zhang, Licheng Zhang, Qingjiong Zhang, Weiqi Zhang, Xinchao Zhang, Xuxiang Zhang, Yan Zhang, Yong Zhang, Yun-Wu Zhang, Zhanjun Zhang, Changqing Zhang, Zhuohua Zhang, Weiping J Zhang, Xiaoqing Zhang, Zhen-Lin Zhang, Jiajun Zhao, Tongbiao Zhao, Yuzheng Zhao, Jialin C Zheng, Zhuozhao Zheng, Zhongjun Zhou, Zhiming Zhu, Wenjuan Zhuang, Weiguo Zou

Affiliations

¹ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
² School of Life Sciences, Jilin University, Changchun, China.
³ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
⁴ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. qujing@ioz.ac.cn.
⁵ University of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
⁶ Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. qujing@ioz.ac.cn.
⁷ University of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
⁸ China National Center for Bioinformation, Beijing, China. zhangwq@big.ac.cn.
⁹ Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
¹⁰ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
¹¹ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
¹² University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
¹³ National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.

PMID: 40935898
DOI: 10.1038/s41580-025-00883-8

Abstract

Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

References

1. Cai, Y. et al. The landscape of aging. Sci. China Life Sci. 65, 2354–2454 (2022). - PubMed - PMC - DOI
1. Partridge, L., Deelen, J. & Slagboom, P. E. Facing up to the global challenges of ageing. Nature 561, 45–56 (2018). - PubMed - DOI
1. Chang, A. Y., Skirbekk, V. F., Tyrovolas, S., Kassebaum, N. J. & Dieleman, J. L. Measuring population ageing: an analysis of the Global Burden of Disease Study 2017. Lancet Public Health 4, e159–e167 (2019). - PubMed - PMC - DOI
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Biomarkers of ageing of humans and non-human primates

Collaborators

Affiliations

Biomarkers of ageing of humans and non-human primates

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources