Exploring efficient therapy for cutaneous neoplasm using gel formulations

Abstract

Objective: This review examines the pathology and treatment of cutaneous neoplasms, highlighting the limitations of conventional therapies and the potential of gel-based drug delivery systems for the efficient treatment of localized skin cancer.

Significance: Skin cancer, including melanoma and non-melanoma types, has a growing concern in global health with increasing incidence due to UV exposure and lifestyle changes. Conventional therapies such as chemotherapy and radiation are often limited by systemic toxicity, drug resistance and poor skin barrier penetration. Gel-based drug delivery systems, including hydrogels, nanogels, and liposome gels, offer innovative solutions by improving drug stability enabling controlled release, and reducing adverse effects. These systems enhance localized treatment by improving drug retention and targeted delivery.

Key findings: Conventional treatments face challenges such as high toxicity and inefficient drug penetration. Gel-based drug delivery systems provide enhanced drug stability, controlled release, and better skin permeability. Stimuli-responsive gels, which react to environmental factors like pH and temperature, optimize drug absorption and therapeutic efficacy while minimizing side effects. These systems address key challenges in cutaneous neoplasm therapy by improving drug delivery and patient outcomes.

Conclusion: Gel-based drug delivery systems offer a promising advancement in skin cancer treatment. Their ability to enhance drug stability, provide targeted delivery, and reduce toxicity suggests a shift toward more effective and patient-friendly therapeutic strategies, ultimately improving treatment outcomes.

Keywords: Cutaneous neoplasms; gel; hydrogel; liposome gel; nanogel.