High Oscillometry-derived Airway Resistance Is Associated with FEV₁ Decline and Future Abnormal Spirometry in Smokers with Initially Normal Spirometry

Mustafa Abdo^{1

2

3}, Frederik Trinkmann^{3

4}, Ralf Ewert⁵, Anne Obst⁵, Henry Völzke⁶, Claudia Flexeder^{7

8

9}, Margit Heier⁸, Annette Peters^{10

8}, Felix Herth^{3

4}, Henrik Watz^{3

11}, Klaus F Rabe^{1

3

12}, Beate Stubbe⁵, Stefan Karrasch^{7

8

9}

Affiliations

¹ LungenClinic Grosshansdorf, Airway Research Center North, Grosshansdorf, Germany.
² Internal Medicine Department I, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany.
³ German Center for Lung Research (DZL) and.
⁴ Department of Respiratory and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, Heidelberg, Germany.
⁵ Department of Internal Medicine B and.
⁶ Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
⁷ Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, and.
⁸ Institute of Epidemiology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany.
⁹ Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich, Munich, Germany.
¹⁰ Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.
¹¹ Velocity Clinical Research (formerly Pulmonary Research Institute), Ahrensburg, Germany; and.
¹² Department of Pulmonary Medicine, Christian Albrechts University Kiel, Kiel, Germany.

PMID: 40938655
DOI: 10.1164/rccm.202507-1645RL

High Oscillometry-derived Airway Resistance Is Associated with FEV₁ Decline and Future Abnormal Spirometry in Smokers with Initially Normal Spirometry

Mustafa Abdo et al. Am J Respir Crit Care Med. 2025 Nov.

. 2025 Nov;211(11):2142-2145.

doi: 10.1164/rccm.202507-1645RL.

Authors

Affiliations

¹ LungenClinic Grosshansdorf, Airway Research Center North, Grosshansdorf, Germany.
² Internal Medicine Department I, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany.
³ German Center for Lung Research (DZL) and.
⁴ Department of Respiratory and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, Heidelberg, Germany.
⁵ Department of Internal Medicine B and.
⁶ Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
⁷ Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, and.
⁸ Institute of Epidemiology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany.
⁹ Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich, Munich, Germany.
¹⁰ Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.
¹¹ Velocity Clinical Research (formerly Pulmonary Research Institute), Ahrensburg, Germany; and.
¹² Department of Pulmonary Medicine, Christian Albrechts University Kiel, Kiel, Germany.