Cardiopulmonary vagal afferents in the monkey: a survey of receptor activity

Abstract

A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricular receptor, 7 type A atrial receptors and 24 type B atrial receptors. The response of each cardiovascular receptor was tested by altering the stimulus for their discharge. Aortic and ventricular baroreceptors increased their discharge in response to an increase in blood pressure induced by intravenous norepinephrine. Type A atrial receptors did not increase their discharge in response to an increase in atrial pressure during intravenous administration of isotonic saline, while type B atrial receptors did. The discharge of the latter became continuous following the intravenous administration of veratridine sulphate (20 microgram). It is concluded that the basic types of cardiopulmonary afferents exist in the non-human primate and that they respond similarly to those which have been demonstrated in lower species.