Phase separation in frozen erythrocyte membrane preparations
- PMID: 4093969
- DOI: 10.1111/j.1365-2818.1985.tb02664.x
Phase separation in frozen erythrocyte membrane preparations
Abstract
The reversible formation of a lipid-like phase in frozen preparations of erythrocyte membranes has been studied by X-ray diffraction and by electron microscopy of freeze-fracture replicas. The observations provide strong evidence for lateral migration or displacement at specific temperatures of intra-membrane particles. This creates large areas of particle-free membranes which fracture preferentially so as to dominate the freeze-fracture image.
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