Raman studies of structural rearrangements induced in human plasma lipoprotein carotenoids by malondialdehyde
- PMID: 4094519
- DOI: 10.1007/BF02534773
Raman studies of structural rearrangements induced in human plasma lipoprotein carotenoids by malondialdehyde
Abstract
Raman and resonance Raman spectra of plasma lipoproteins +/- malondialdehyde were studied at concentrations which block the normal receptor-mediated uptake by cells. The strong resonance Raman bands at about 1010, 1162 and 1530 cm-1, due to the presence of carotenoids in the lipoproteins, are envisaged as structural probes. High resolution resonance Raman spectra of the 1500-1600 cm-1 region reveal multiple features suggesting the coexistence of several structural populations of beta-carotene whose precise assignment is complex. When plasma lipoproteins are reacted with malondialdehyde, a complex change occurs in the resonance Raman banding of beta-carotene in the 1500-1600 cm-1 region. Malonaldehyde (MDA) also modifies the acoustical region (70-200 cm-1 of low density lipoprotein (LDL) lipids. We suggest that malondialdehyde association with plasma lipoproteins alters the lipid structure via apoprotein or apoprotein/lipid associations.
Similar articles
-
Resonance Raman spectra of beta-carotene in native and modified low-density lipoprotein.Biochem Biophys Res Commun. 1984 Jul 31;122(2):867-75. doi: 10.1016/s0006-291x(84)80114-x. Biochem Biophys Res Commun. 1984. PMID: 6087818
-
Changes of apolipoprotein B molecular weight and immunoreactivity in malondialdehyde-modified low density lipoproteins.Artery. 1983;12(2):74-80. Artery. 1983. PMID: 6431946
-
Localization of carotenoids in plasma low-density lipoproteins studied by surface-enhanced resonance Raman spectroscopy.Biopolymers. 2000;57(4):249-56. doi: 10.1002/1097-0282(2000)57:4<249::AID-BIP6>3.0.CO;2-1. Biopolymers. 2000. PMID: 10861389
-
[Apoproteins in dyslipoproteinemia (author's transl)].Diabete Metab. 1981 Mar;7(1):51-61. Diabete Metab. 1981. PMID: 6786929 Review. French.
-
[Plasma lipoproteins and apolipoproteins].Z Gesamte Inn Med. 1979 May 1;34(9):241-6. Z Gesamte Inn Med. 1979. PMID: 225895 Review. German.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources