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. 2025 Sep 13.
doi: 10.1245/s10434-025-18306-5. Online ahead of print.

Association Between Postoperative Skeletal Muscle Loss and Disease-Free Survival in Node-Negative NSCLC ≤ 4 cm Without Adjuvant Therapy: A 5-Years Trend Analysis

Arsalan A Khan  1 , Wara Naeem  1 , Savan K Shah  1 , Minha Ansari  1 , Gillian C Alex  1 , Nicole M Geissen  1 , Michael J Liptay  1 , Christopher W Seder  2
Affiliations

Association Between Postoperative Skeletal Muscle Loss and Disease-Free Survival in Node-Negative NSCLC ≤ 4 cm Without Adjuvant Therapy: A 5-Years Trend Analysis

Arsalan A Khan et al. Ann Surg Oncol. .

Abstract

Background: Despite advances in treatment, approximately 20% of patients with early stage non-small cell lung cancer (NSCLC) will experience recurrence. Sarcopenia has emerged as a potential prognostic factor in lung cancer. We hypothesize that rate of skeletal muscle volume loss after lung resection is associated with disease-free survival (DFS).

Patients and methods: A retrospective analysis was conducted on 316 patients with node-negative NSCLC (≤ 4 cm) who underwent lung resection between 2010 and 2021. Those receiving neoadjuvant or adjuvant therapy or experiencing recurrence within 12 months of surgery were excluded. Skeletal muscle index (SMI) was measured preoperatively and annually for up to 5 years. Locally estimated scatterplot smoothing (LOESS) regression was used to visualize trends in SMI over time, and cut-point analysis identified the optimal slope of SMI change associated with DFS. The association between SMI slope and DFS was further evaluated using multivariable Cox proportional hazards models, adjusting for relevant demographic and clinical covariates.

Results: LOESS analysis revealed an initial plateau in SMI during the first postoperative year across all patients, followed by a marked decline in patients that recurred. The greatest loss in SMI occurred in the year immediately preceding radiographic identification of recurrence. In Cox proportional hazards analysis, patients with an SMI loss greater than 13.5 units/year had worse DFS (hazard ratio [HR] 11.97, 95% confidence interval [CI] 5.54-25.87, p < 0.001).

Conclusions: Rate of skeletal muscle loss after lung resection may be an early marker for NSCLC recurrence, underscoring the need for longitudinal SMI monitoring as part of routine postoperative surveillance.

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Conflict of interest statement

DISCLOSURES: The authors have no potential conflicts of interest. The authors received no financial support for the research, authorship, or publication of this article. Informed Consent: Waiver obtained for retrospective review (18070602-IRB01), approved 19 December 2023.

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