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. 2025 Dec;21(6):1557-1564.
doi: 10.1016/j.jpurol.2025.08.031. Epub 2025 Sep 1.

Urethrocutaneous fistula recurrence after hypospadias repair: Risk factors and recurrence rates in a 20-year single-center experience

Sylvia Weis  1 , Alaa El-Ghoneimi  2 , Ugo Maria Pierucci  3 , Amane A Lachkar  2 , Valeska Bidault-Jourdainne  4 , Annabel Paye  2 , Matthieu Peycelon  5
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Urethrocutaneous fistula recurrence after hypospadias repair: Risk factors and recurrence rates in a 20-year single-center experience

Sylvia Weis et al. J Pediatr Urol. 2025 Dec.

Abstract

Purpose: To study the outcomes, risk factors, and timing of fistula recurrence after surgical repair of urethrocutaneous fistula (UCF) in children with hypospadias.

Methods: 102 patients with a complete follow-up (>5 months) who had a fistula repair after hypospadias surgery were retrospectively analyzed (2000-2023). Median (IQR) age and follow-up were 3.5 years (2-6) and 26 months (12-57), respectively. Analyzed data included demographics; type of hypospadias, urethroplasty and fistula repair; fistula characteristics, and complications.

Statistical analysis: Mann-Whitney U, Fisher's exact, and Chi-square tests.

Results: The 2-year fistula recurrence rate was 23.5 %. Significant risk factors for secondary fistula recurrence after repair included: fistula size of 2-4 mm, previous fistula repair performed at another center, and the total number of fistula recurrences. Fistula repair using a skin flap was associated with a lower rate of recurrence. The median (IQR) and mean time to fistula recurrence were 10 (5.5-40) and 30 months respectively. Fistula recurrence occurred in 54.2 % within the first 12 months post-surgery and in 45.8 % after 12 months. No significant differences were observed regarding the type of hypospadias, the technique used for hypospadias repair, single-stage versus two-stage surgery, postoperative complications (including meatal stenosis and urethral strictures), fistula characteristics (location and number), or different surgeons performing the hypospadias and fistula repairs.

Conclusion: The risk of secondary fistula recurrence increased with a fistula size of 2-4 mm and the total number of recurrences. Using a skin flap reduced the recurrence rate. We recommend a minimum follow-up of 12 months, as nearly 50 % of recurrences occur in the medium-to long-term.

Keywords: Fistula repair; Hypospadias; Postoperative complications; Recurrence rate; Skin flap; Urethrocutaneous fistula.

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Conflict of interest statement

Conflicts of interest Disclosure of potential conflicts of interest: The authors have no relevant financial or non-financial interests to disclose. Research involving Human Participants and/or Animals: As this was a retrospective study, it did not contain any contact with human participants or animals performed by any of the authors. Local law does not require ethics committee approval or informed consent for retrospective data collection. Informed consent: Local law does not require ethics committee approval or informed consent for retrospective data collection.

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