Long-term survival outcomes of lorlatinib in advanced anaplastic lymphoma kinase (ALK)-fusion positive non-small cell lung cancer
- PMID: 40948845
- PMCID: PMC12432676
- DOI: 10.21037/tlcr-2025-564
Long-term survival outcomes of lorlatinib in advanced anaplastic lymphoma kinase (ALK)-fusion positive non-small cell lung cancer
Keywords: Anaplastic lymphoma kinase (ALK); alectinib; brain metastasis; brigatinib; lorlatinib.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-564/coif). M.M. reports lecture fees from Taiho, Boehringer-ingelheim, Daiichi Sankyo, Eli Lilly, Chugai, Astra Zeneca, Ono, Pfizer, and MSD; other (principal investigator of pharmaceutical companies initiated trial) from Chugai, Astra Zeneca, Ono, Pfizer, Merk Serono, Kissei, Taiho, and Novartis; and research grants from Boehringer-ingelheim, and Eli Lilly, outside the submitted work. I.T. received research funding from Chugai Pharmaceutical Co.; and reports consulting/advisory roles: AstraZeneca; honoraria: AstraZeneca, Chugai Pharmaceuticals, Bristol-Myers Squibb, MSD K.K, Novartis Pharma K.K., Takeda Pharmaceuticals, Ono Pharmaceutical Co. and Daiichi Sankyo Company. The other author has no conflicts of interest to declare.
Comment on
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Final Overall Survival and Long-Term Safety of Lorlatinib in Patients With ALK-Positive NSCLC From the Pivotal Phase 2 Study: A Brief Report.J Thorac Oncol. 2025 Apr;20(4):513-520. doi: 10.1016/j.jtho.2024.11.021. Epub 2024 Nov 22. J Thorac Oncol. 2025. PMID: 39581380 Clinical Trial.
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