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Editorial
. 2025 Aug 31;14(8):2922-2927.
doi: 10.21037/tlcr-2025-564. Epub 2025 Aug 22.

Long-term survival outcomes of lorlatinib in advanced anaplastic lymphoma kinase (ALK)-fusion positive non-small cell lung cancer

Affiliations
Editorial

Long-term survival outcomes of lorlatinib in advanced anaplastic lymphoma kinase (ALK)-fusion positive non-small cell lung cancer

Masahiro Morise et al. Transl Lung Cancer Res. .
No abstract available

Keywords: Anaplastic lymphoma kinase (ALK); alectinib; brain metastasis; brigatinib; lorlatinib.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-564/coif). M.M. reports lecture fees from Taiho, Boehringer-ingelheim, Daiichi Sankyo, Eli Lilly, Chugai, Astra Zeneca, Ono, Pfizer, and MSD; other (principal investigator of pharmaceutical companies initiated trial) from Chugai, Astra Zeneca, Ono, Pfizer, Merk Serono, Kissei, Taiho, and Novartis; and research grants from Boehringer-ingelheim, and Eli Lilly, outside the submitted work. I.T. received research funding from Chugai Pharmaceutical Co.; and reports consulting/advisory roles: AstraZeneca; honoraria: AstraZeneca, Chugai Pharmaceuticals, Bristol-Myers Squibb, MSD K.K, Novartis Pharma K.K., Takeda Pharmaceuticals, Ono Pharmaceutical Co. and Daiichi Sankyo Company. The other author has no conflicts of interest to declare.

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References

    1. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6. 10.1038/nature05945 - DOI - PubMed
    1. Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 2014;371:2167-77. 10.1056/NEJMoa1408440 - DOI - PubMed
    1. Hida T, Nokihara H, Kondo M, et al. Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial. Lancet 2017;390:29-39. 10.1016/S0140-6736(17)30565-2 - DOI - PubMed
    1. Peters S, Camidge DR, Shaw AT, et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer. N Engl J Med 2017;377:829-38. 10.1056/NEJMoa1704795 - DOI - PubMed
    1. Zhou C, Kim SW, Reungwetwattana T, et al. Alectinib versus crizotinib in untreated Asian patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer (ALESIA): a randomised phase 3 study. Lancet Respir Med 2019;7:437-46. 10.1016/S2213-2600(19)30053-0 - DOI - PubMed

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