The OPEN trial-from the darkness, comes light
- PMID: 40948852
- PMCID: PMC12432590
- DOI: 10.21037/tlcr-2025-363
The OPEN trial-from the darkness, comes light
Keywords: Epidermal growth factor receptor-mutant (EGFR-mutant); non-small cell lung cancer (NSCLC); osimertinib; poor performance status (poor PS).
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-2025-363/coif). S.A. receives speaker fees from Merck-Sharpe & Dohme, Astra Zeneca, Roche, Bristol-Myer Squibb, Merck Serono, Takeda, Medwise consulting and Amgen; receives travel support from Astra Zeneca, Roche, Merck-Sharpe & Dohme and Pfizer; and is on the advisory board for Roche, BeiGene, Amgen, Bayer, Astra Zeneca, Merck-Sharpe & Dohme, Johnson & Johnson, Bristol-Myer Squibb and Medison. The other author has no conflicts of interest to declare.
Comment on
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A Prospective Phase II Trial of First-Line Osimertinib for Patients With EGFR Mutation-Positive NSCLC and Poor Performance Status (OPEN/TORG2040).J Thorac Oncol. 2025 May;20(5):665-675. doi: 10.1016/j.jtho.2024.12.027. Epub 2025 Jan 2. J Thorac Oncol. 2025. PMID: 39755169 Clinical Trial.
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