Balancing evidence and individualization in adjuvant CDK4/6 therapy
- PMID: 40950694
- PMCID: PMC12432663
- DOI: 10.21037/tcr-2025-879
Balancing evidence and individualization in adjuvant CDK4/6 therapy
Keywords: Breast; cancer; cyclin-dependent kinase 4 and 6 therapy (CDK4/6 therapy).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-2025-879/coif). K.M. is a fractional shareholder of Datar Genetics’ stock. K.M. has received honoraria for offering academic and clinical advice to Merit Medical and QMedical corporations. Furthermore, he owns shares in HCA Healthcare UK. The other authors have no conflicts of interest to declare.
Comment on
-
Why We Do Not Recommend That Women With Breast Cancer Receive Adjuvant Treatment With a CDK4/6 Inhibitor.J Clin Oncol. 2025 Aug;43(22):2456-2460. doi: 10.1200/JCO-24-02683. Epub 2025 Apr 14. J Clin Oncol. 2025. PMID: 40228181 No abstract available.
References
-
- NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Breast Cancer. Version 1.2025.
-
- Saad ED, Squifflet P, Burzykowski T, et al. Disease-free survival as a surrogate for overall survival in patients with HER2-positive, early breast cancer in trials of adjuvant trastuzumab for up to 1 year: a systematic review and meta-analysis. Lancet Oncol 2019;20:361-70. 10.1016/S1470-2045(18)30750-2 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources