Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Aug 31;17(8):6351-6355.
doi: 10.21037/jtd-2025-760. Epub 2025 Aug 27.

Debunking a one-size-fits-all in acute respiratory failure: lessons from the RENOVATE trial

Dominic C Marshall  1 , Malcolm Lemyze  2
Affiliations
Editorial

Debunking a one-size-fits-all in acute respiratory failure: lessons from the RENOVATE trial

Dominic C Marshall et al. J Thorac Dis. .
No abstract available

Keywords: High flow oxygen; acute respiratory failure (ARF); non-invasive ventilation.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-760/coif). D.C.M. is supported by an MRC clinical research training fellowship (award MR/Y000404/1) and the Mittal Fund at Cleveland Clinic Philanthropy. The other author has no conflicts of interest to declare.

Comment on

  • High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial.
    RENOVATE Investigators and the BRICNet Authors; Maia IS, Kawano-Dourado L, Tramujas L, de Oliveira NE, Souza RN, Signorini DF, Pincelli MP, Zandonai CL, Blasius RT, Freires F, Ferreira VM, Romano MLP, Miura MC, de Censo CM, Caser EB, Silva B, Santos Bonomo DC, Arraes JA, de Alencar Filho MS, Álvares Horta JG, Oliveira DC, Boschi E, Costa RL, Westphal GA, Ramos J, Lacerda FH, Filho CRH, Pinheiro BV, de Andrade Neumamm LB, Guimarães Júnior MRR, de Souza DT, Ferreira JC, Ohe LN, Schettini DA, Thompson MM, de Oliveira MCF, Veiga VC, Negrelli KL, Santos RHN, Damiani L, Gurgel RM, Gomes SPC, Lima LM, Miranda TA, Laranjeira LN, de Barros E Silva PGM, Machado FR, Fitzgerald M, Bosse A, Marion J, Carvalho CRR, Brochard L, Lewis RJ, Biasi Cavalcanti A. RENOVATE Investigators and the BRICNet Authors, et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. JAMA. 2025. PMID: 39657981 Free PMC article. Clinical Trial.

References

    1. O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax 2017;72:ii1-ii90. 10.1136/thoraxjnl-2016-209729 - DOI - PubMed
    1. Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J 2017;50:1602426. 10.1183/13993003.02426-2016 - DOI - PubMed
    1. Seow D, Khor YH, Khung SW, et al. High-flow nasal oxygen therapy compared with conventional oxygen therapy in hospitalised patients with respiratory illness: a systematic review and meta-analysis. BMJ Open Respir Res 2024;11:e002342. 10.1136/bmjresp-2024-002342 - DOI - PMC - PubMed
    1. Parke RL, McGuinness SP. Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle. Respir Care 2013;58:1621-4. 10.4187/respcare.02358 - DOI - PubMed
    1. Groves N, Tobin A. High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care 2007;20:126-31. 10.1016/j.aucc.2007.08.001 - DOI - PubMed

LinkOut - more resources