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. 2025 Sep;207(3):1143-1147.
doi: 10.1111/bjh.20236. Epub 2025 Jul 3.

Anti-CD19 CAR T-cell therapy for patients with Richter transformation: A LYSA study from the DESCAR-T registry

Hedi Bensaber  1 , Emmanuel Ferrant  2 , Rémy Duléry  3 , David Beauvais  4 , Pierre Feugier  5 , Thomas Gastinne  6 , Bruno Villemagne  7 , Etienne Paubelle  8 , Cristina Castilla Llorente  9 , Louise Roulin  10 , Thomas Longval  11 , Amandine Fayard  1 , Jacques-Olivier Bay  1 , Steven Le Gouill  12 , Elodie Gat  13 , Marie de Antonio  14 , Franck Morschhauser  4 , Romain Guièze  1
Affiliations

Anti-CD19 CAR T-cell therapy for patients with Richter transformation: A LYSA study from the DESCAR-T registry

Hedi Bensaber et al. Br J Haematol. 2025 Sep.
No abstract available

Keywords: CAR‐T cell therapy; Richter transformation; chronic lymphocytic leukaemia.

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References

REFERENCES

    1. Thompson PA, Siddiqi T. Treatment of Richter's syndrome. Hematol Am Soc Hematol Educ Program. 2022;2022(1):329–336.
    1. Parikh SA, Kay NE, Shanafelt TD. How we treat Richter syndrome. Blood. 2014;123(11):1647–1657.
    1. Langerbeins P, Busch R, Anheier N, Dürig J, Bergmann M, Goebeler ME, et al. Poor efficacy and tolerability of R‐CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation. Am J Hematol. 2014;89(12):E239–E243.
    1. Eyre TA, Clifford R, Bloor A, Boyle L, Roberts C, Cabes M, et al. NCRI phase II study of CHOP in combination with ofatumumab in induction and maintenance in newly diagnosed Richter syndrome. Br J Haematol. 2016;175(1):43–54.
    1. Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, et al. Axicabtagene Ciloleucel CAR T‐cell therapy in refractory large B‐cell lymphoma. N Engl J Med. 2017;377(26):2531–2544.

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