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Review
. 2025 Jul-Sep;31(3):14604582251381270.
doi: 10.1177/14604582251381270. Epub 2025 Sep 16.

Validation of the transformed clinical practice research datalink (CPRD) GOLD and aurum data into the OMOP common data model

George Kafatos  1 , Joe Maskell  1 , Olia Archangelidi  1 , David Neasham  1
Affiliations
Free article
Review

Validation of the transformed clinical practice research datalink (CPRD) GOLD and aurum data into the OMOP common data model

George Kafatos et al. Health Informatics J. 2025 Jul-Sep.
Free article

Abstract

Objective: To assesses the transformation of UK Clinical Practice Research Datalink (CPRD) databases into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) version 5.3.1. Methods: A systematic approach was used to generate medical code lists and compare prevalent and incident counts between the source and OMOP CDM versions. Results: The results showed, for CPRD General Practitioner Online Database (GOLD) database, 89.5% of clinical events had no or very small differences in prevalent and incident event counts between the two versions of the database. The differences for CPRD Aurum were even smaller, with 97.4% of events showing no or very small differences in counts between the source and OMOP versions. Some observed discrepancies were due to codes being mapped into different tables. Conclusion: The study findings confirm the consistency of the OMOP transformation and provide confidence in analyses that query CPRD OMOP-transformed data.

Keywords: CPRD Aurum; CPRD GOLD; OMOP; medical codes.

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Conflict of interest statement

Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: GK, JM, OA and DN are Amgen Ltd employees and own Amgen Inc shares.

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