Regulatory genome annotation

Sushant Kumar^{1

2}, Mark Gerstein^{3

4

5}

Affiliations

¹ Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. sushant.kumar@utoronto.ca.
² Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. sushant.kumar@utoronto.ca.
³ Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA. mark@gersteinlab.org.
⁴ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. mark@gersteinlab.org.
⁵ Department of Statistics and Data Science, Yale University, New Haven, CT, USA. mark@gersteinlab.org.

Sushant Kumar et al. Nat Rev Genet. 2025 Oct.

. 2025 Oct;26(10):661-662.

doi: 10.1038/s41576-025-00885-4.

Sushant Kumar^{1

2}, Mark Gerstein^{3

4

5}

¹ Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. sushant.kumar@utoronto.ca.
² Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. sushant.kumar@utoronto.ca.
³ Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA. mark@gersteinlab.org.
⁴ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. mark@gersteinlab.org.
⁵ Department of Statistics and Data Science, Yale University, New Haven, CT, USA. mark@gersteinlab.org.

No abstract available

Conflict of interest statement

Competing interests: The authors declare no competing interests.

1. Gerstein, M. B. et al. Architecture of the human regulatory network derived from ENCODE data. Nature 489, 91–100 (2012). - DOI - PubMed - PMC
1. The ENCODE Project Consortium et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature 583, 699–710 (2020). - DOI
1. Gong, D., Arbesfeld-Qiu, J. M., Perrault, E., Bae, J. W. & Hwang, W. L. Spatial oncology: translating contextual biology to the clinic. Cancer Cell 42, 1653–1675 (2024). - DOI - PubMed
1. Coorens, T. H. H. et al. The human and non-human primate developmental GTEx projects. Nature 637, 557–564 (2025). - DOI - PubMed - PMC
1. Rozowsky, J. et al. The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models. Cell 186, 1493–1511.e40 (2023). - DOI - PubMed - PMC