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Multicenter Study
. 2025 Nov;39(11):748-754.
doi: 10.1038/s41371-025-01067-9. Epub 2025 Sep 16.

The association of area deprivation index and blood pressure control and therapeutic inertia among older adults with hypertension

Affiliations
Multicenter Study

The association of area deprivation index and blood pressure control and therapeutic inertia among older adults with hypertension

Michael T Saban et al. J Hum Hypertens. 2025 Nov.

Abstract

Neighborhood characteristics may influence patient and clinician management of blood pressure (BP) control. This study examined the association of the Area Deprivation Index (ADI) with uncontrolled BP ( ≥ 140/90 mmHg) at primary care visits and therapeutic inertia (TI) during visits with uncontrolled BP. Data included 52 750 visits among 8 434 patients aged ≥65 years across nine outpatient clinics in Chicago suburbs between January 1, 2017, and March 10, 2020. ADI represents national percentiles of census block group deprivation (0 = least, 100 = most deprived). TI was defined as no initiation or escalation of BP-lowering medication during visits with uncontrolled BP. Adjusted prevalence ratios (PRs) of uncontrolled BP and TI by ADI quartiles were estimated using generalized estimating equations. Mean age was 74.3 years (SD 7.8), 42.3% were male, 69.1% Non-Hispanic (NH) White, 15.9% NH Black, and 8.2% Hispanic. Uncontrolled BP occurred in 33.8% of visits. Of those, 73.4% experienced TI. There was no significant association between ADI and uncontrolled BP in adjusted models. Adjusted PRs of TI were higher in ADI Q2 (PR 1.03, 95% CI: 1.00-1.06) and Q3 (PR 1.04 (95% CI: 1.01-1.07), but not Q4 compared to Q1. ADI modeled continuously with splines showed modest increases in adjusted predicted prevalence of both outcomes, although confidence intervals widened at the extremes. Neighborhood deprivation may contribute to disparities in hypertension management but more studies with larger number of patient visits at the extremes of ADI distribution are needed.

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethical approval: This study was reviewed by the Loyola University Chicago Institutional Review Board and deemed exempt from human subjects review. All methods were carried out in accordance with relevant guidelines and regulations. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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