Recent Advances in Cobalt-Catalyzed Oxidative C-H Activation

Abstract

The importance of C-H activation in organic chemistry lies in its transformative potential and impact across various fields. Cobalt-catalyzed C-H activation has roots in transition-metal catalysis dating back to the mid-20th century. However, the specific use of cobalt as a catalyst for oxidative C-H activation gained attraction more recently. New advancements have broadened the scope of cobalt-catalyzed C-H activation to encompass a variety of substrates and transformations. C-H activation plays a pivotal role in modern organic chemistry by offering efficient, versatile, and sustainable methods for the synthesis of complex molecules, thereby driving innovation and discovery in science and technology. This review focuses on the recent developments in oxidative cobalt-catalyzed C-H activation covering literature from 2020-2024.

Keywords: atom‐economy; cobalt; electrocatalysis; oxidative C‐H activation; sustainability.