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. 2025 Sep 17.
doi: 10.1245/s10434-025-18377-4. Online ahead of print.

ASO Author Reflections: Predictors of Immune Checkpoint Inhibitor Response in ER+/HER2- Breast Cancer: A New Role for ESR1?

Jun Arima #  1   2 , Kohei Chida #  1   3 , Rongrong Wu  1   4 , Kohei Taniguchi  5 , Amber McKenery  6 , Brian G Morreale  7 , Andrea M Monell  7 , Scott I Abrams  7 , John M L Ebos  6 , Kenichi Hakamada  3 , Takashi Ishikawa  4 , Seita Hagihara  2 , Nao Kawaguchi  2 , Toru Kuramoto  2 , Takafumi Shima  2 , Hiroki Hamamoto  2 , Ryo Tanaka  2 , Yoshiro Imai  2 , Kosei Kimura  2 , Mitsuhiko Iwamoto  2 , Sang-Woong Lee  2 , Kazuaki Takabe  8   9   10   11   12   13
Affiliations

ASO Author Reflections: Predictors of Immune Checkpoint Inhibitor Response in ER+/HER2- Breast Cancer: A New Role for ESR1?

Jun Arima et al. Ann Surg Oncol. .
No abstract available

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References

    1. Waks AG, Stover DG, Guerriero JL, et al. The immune microenvironment in hormone receptor-positive breast cancer before and after preoperative chemotherapy. Clin Cancer Res. 2019;25:4644–55. - DOI - PubMed
    1. Ríos-Hoyo A, Cobain E, Huppert LA, et al. Neoadjuvant chemotherapy and immunotherapy for estrogen receptor-positive human epidermal growth factor 2-negative breast cancer. J Clin Oncol. 2024;42:2632–6. - DOI - PubMed
    1. Oshi M, Ghasemi F, Yamada A, Yan L, Zhang J, Abrams SI, Endo I, Takabe K. Activated HIPPO pathway is associated with a worse response to trastuzumab and worse survival in HER2-positive breast cancer. Ann Surg Oncol. 2025. https://doi.org/10.1245/s10434-025-17657-3 . - DOI - PubMed
    1. Sharma P, Chida K, Wu R, et al. VEGFA gene expression in breast cancer is associated with worse prognosis, but better response to chemotherapy and immunotherapy. World J Oncol. 2025;16:120–30. - DOI - PubMed - PMC
    1. Arima J, Chida K, Wu R, et al. ESR1 expression negatively correlates with immune cell infiltration and response to immune checkpoint inhibitors in ER-positive HER2-negative breast cancer. Ann Surg Oncol. 2025. https://doi.org/10.1245/s10434-025-18260-2 . - DOI - PubMed

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