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Editorial
. 2025 Sep 17;66(3):2500760.
doi: 10.1183/13993003.00760-2025. Print 2025 Sep.

Multi-omics profiling in severe pneumonia: the importance of robust study design

Benjamin D Singer  1   2   3   4
Affiliations
Editorial

Multi-omics profiling in severe pneumonia: the importance of robust study design

Benjamin D Singer. Eur Respir J. .

Abstract

In this issue of the European Respiratory Journal, Fennell and co-workers report a robust, well-designed study characterising the lung microenvironment of SARS-CoV-2 pneumonia https://bit.ly/4iJbN1d

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Conflict of interest statement

Conflict of interest: B.D. Singer holds US patent number US 10,905,706 B2, “Compositions and Methods to Accelerate Resolution of Acute Lung Inflammation”, and serves on the Scientific Advisory Board of Zoe Biosciences.

Figures

FIGURE 1
FIGURE 1
The alveolar microenvironment in SARS-CoV-2 pneumonia is characterised by diffuse alveolar damage, viral infection of alveolar epithelial cells and macrophages, a myelo-lymphocytic immune infiltrate, and deposition of collagen VI with pro-C6 detectable in the serum. PDL1: programmed death-ligand 1; IDO1: indoleamine 2,3-dioxygenase 1.
See this image and copyright information in PMC

Comment on

  • Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19.
    Fennell É, Taylor GS, Leahy CI, Ross AM, Reynolds G, Perry T, Youd E, Skidmore J, Darwish RRR, Hunter KJ, Willcox BE, Jermann P, Arif Jahangir C, Rahman A, Gallagher WM, Nikulina N, Ben Cheikh B, Braubach O, Mayer AT, Young LS, Grammatopoulos D, Faustini S, Richter A, Dowell AC, Venith T, Thein OS, Parekh D, Belchamber KBR, Thickett DR, Scott A, Attanoos R, Mundo L, Lazzi S, Leoncini L, Leopold G, Steven N, Bülow Sand JM, Karsdal MA, Leeming DJ, Dojcinov S, Culhane A, Murray PG, Pugh MR. Fennell É, et al. Eur Respir J. 2025 Sep 17;66(3):2301699. doi: 10.1183/13993003.01699-2023. Print 2025 Sep. Eur Respir J. 2025. PMID: 40473310 Free PMC article.

References

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    1. Budinger GRS, Misharin AV, Ridge KM, et al. Distinctive features of severe SARS-CoV-2 pneumonia. J Clin Invest 2021; 131: e149412. - PMC - PubMed
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    1. Blanco-Melo D, Nilsson-Payant BE, Liu WC, et al. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell 2020; 181: 1036–1045.e9. - PMC - PubMed

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