Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;26(3):326-39.
doi: 10.1186/BF03546533.

Experimental osteoarthritis in the rabbit. II. A new method to estimate the oxygen consumption and diffusion capacity in the synovial membrane of the knee

E Svalastoga, J Grønlund

Experimental osteoarthritis in the rabbit. II. A new method to estimate the oxygen consumption and diffusion capacity in the synovial membrane of the knee

E Svalastoga et al. Acta Vet Scand. 1985.

Abstract
in English, Norwegian

The oxygen supply to the joint cartilage depends on the oxygen transport from the capsular arteries to the capillaries, the oxygen diffusion across the synovial membrane and the oxygen transport through the synovia. In osteoarthritis the resistance to transport across all 3 barriers may be increased because of the joint effusion, the elevated intraarticular pressure and the inflammatory changes of the synovial membrane.

In the present study we describe a method to determine 2 important parameters affecting the oxygen transport through the synovial membrane: the oxygen consumption and diffusion capacity of the membrane. The principle of the method is to perfuse the joint cavity of the knee by saline saturated with air and to record the relationship between the oxygen partial pressure in the outflowing perfusate and the perfusion rate.

The values found for the diffusion capacity and oxygen consumption were 0.039 ± 0.013 μl O2/min/Torr and 0.93 ± 0.90 μl O2/min (mean ± s).

Iltforsyningen til den hyaline ledbrusk er afhængig af transport fra kapselarterierne til kapillærerne, diffusion over synovialmembranen, samt transport gennem synovi. Osteoartritis og andre effusive ledlidelser kan hypotetisk medføre en nedsat ilt overførsel over alle tre barrierer. I nærværende arbejde redegøres for en ny metode baseret på ledperfusion til bestemmelse af synovialmembranens metabolisme og diffusionskapacitet in vivo.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ahlqvist J. A hypothesis on the pathogenesis of rheumatoid and other non-specific synovitides. Medical Hypotheses. 1984;13:257–302. doi: 10.1016/0306-9877(84)90162-2. - DOI - PubMed
    1. Bartels H., Harms H. Sauerstoffdissoziationskurven des Blutes von Säugetieren. (Oxygen dissociation curves in mammal blood). Pflügers Arch. 1959;268:334–365. - PubMed
    1. Gill P. E., Murray W. Algorithms for the solution of the non-linear least squares problem. SIAM Journal on Numerical Analysis. 1978;15:977–992. doi: 10.1137/0715063. - DOI
    1. Goetzl E. J., Falchuk K. H., Zeiger L. S., Sullivan A. L., Hebert C. L., Adams J. P., Decker L. A physiological Approach to the Assessment of Disease Activity in Rheumatoid Arthritis. J. clin. Invest. 1971;50:1167–1179. doi: 10.1172/JCI106594. - DOI - PMC - PubMed
    1. Grønlund J. Errors due to data reduction in single-breath method for measurement of pulmonary blood flow. J. appl. Physiol. 1982;52:104–108. doi: 10.1152/jappl.1982.52.1.104. - DOI - PubMed

Publication types

LinkOut - more resources