Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;26(3):340-51.
doi: 10.1186/BF03546534.

Experimental osteoarthritis in the rabbit. III. Acute osteoarthritis: subchondral P02 and oxygen consumption and diffusion capacity in the synovial membrane

E Svalastoga, J Grønlund

Experimental osteoarthritis in the rabbit. III. Acute osteoarthritis: subchondral P02 and oxygen consumption and diffusion capacity in the synovial membrane

E Svalastoga et al. Acta Vet Scand. 1985.

Abstract
in English, Norwegian

The earliest sign of osteoarthritis is acute synovitis with joint effusion and elevated intraarticular pressure, which causes compression of the intracapsular vein segments draining the epiphyseal bone compartment. The increased outflow resistance may cause a fall in the regional blood flow and thereby lead to a state of tissue hypoxia. The acute osteoarthritis may also affect the transfer of oxygen to the cartilage across synovial membrane because of the extensive inflammation with hypercellularity and edema.

In the present study we have investigated the subchondral P02 and Pc02 in acute osteoarthritis. There was no significant difference between these gas tensions in the normal and osteoarthritic bone. We have also investigated the oxygen consumption and diffusion capacity in the synovial membrane. The latter was decreased by a factor of 4 in the osteoarthritic joints whilst the oxygen consumption was increased by a factor of 3.

I de tidlige stadier af osteoartritis er der som følge af ledeffusion og øget intraartikulært tryk en øget udløbsmodstand fra det subchondrale knoglekompartment. Dette kan medføre et fald i det regionale blood flow og dermed føre til subchondral hypoxi. Desuden er Synovialmembranen inflammeret i de tidlige stadier med hypercellularitet og ødem, hvilket vil kunne nedsætte iltoverførslen fra kapillærerne til synovi.

I nærværende arbejde har vi ikke kunnet påvise ændringer i de subchondrale gastensioner i det akutte stadium men synovialmembranens metabolisme var øget med en faktor 3 og diffusionskapaciteten nedsat med en faktor 4.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Arnoldi C. C., Lemberg R. L., Linderholm H. Immediate effect of osteotomy on the intramedullary pressure of the femoral head and neck in patients with degenerative osteoarthritis. Acta orthop. scand. 1971;42:357–365. doi: 10.3109/17453677108989056. - DOI - PubMed
    1. Arnoldi, C. C., H. Linderholm & H. Müssbichler: Venous engorgement and intraosseous hypertension in osteoarthritis of the hip. J. Bone Jt. Surg. 1972, 54B, 409–421. - PubMed
    1. Arnoldi, C. C. & I. Reimann: The pathomechanism of human coxarthrosis. Acta orthop. scand. 1979, Suppl. 181. - PubMed
    1. Arnoldi, C. C., I. Reimann, S. Bach Christensen & S. Mortensen: The effect of increased intra-articular pressure on juxta-articular bone marrow pressure. IRGS Med. Sci. 1979, 7, 471.
    1. Brighton, C. T., R. D. Ray & L. W. Soble: In vitro epiphyseal plate growth in various oxygen tensions. J. Bone Jt. Surg. 1969, 51A, 1383–1396. - PubMed

Publication types

LinkOut - more resources