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. 2025 Sep 26;27(38):10708-10713.
doi: 10.1021/acs.orglett.5c03231. Epub 2025 Sep 18.

Radical Addition-Induced Dearomative Spirocyclization/1,4-Alkyloximation of Unactivated Arenes

Cong Shi  1 , Ruihua Liu  1 , Chao Xie  1 , Zemin Wang  1 , Yuanyuan Zhao  1 , Hongyun Qin  1 , Jia-Shu Chen  1 , Chao Liu  1 , Nan Zhou  1 , Yue Xu  1 , Xiangqian Li  1 , Dayong Shi  1   2   3
Affiliations

Radical Addition-Induced Dearomative Spirocyclization/1,4-Alkyloximation of Unactivated Arenes

Cong Shi et al. Org Lett. .

Abstract

Nitrogenated spirocycles, as integral structural cores of numerous bioactive molecules, are valuable yet synthetically challenging three-dimensional scaffolds. Herein, we report a radical addition-induced dearomative spirocyclization/1,4-alkyloximation of unactivated arenes. The multicomponent protocol concurrently breaks the stable aromatic system and introduces multiple functional groups to synthesize highly decorated nitrogenated spirocycles via a radical cascade process.

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