Embracing Scientific Debate in Brain Metabolism

Jens V Andersen¹, Blanca I Aldana^{1

2}, Lasse K Bak^{1

3

4}, Kevin L Behar⁵, Karin Borges⁶, Anthony Carruthers⁷, Paul Cumming⁸, Amin Derouiche⁹, Carlos M Díaz-García¹⁰, Kelly L Drew¹¹, João M N Duarte^{12

13}, Gustavo C Ferreira¹⁴, Federico Giove¹⁵, Albert Gjedde^{16

17

18}, Fahmeed Hyder¹⁹, Maria S Ioannou²⁰, Oliver Kann²¹, Tibor Kristian²², James C K Lai^{23

24}, Graeme F Mason²⁵, Ewan C McNay²⁶, Maiken Nedergaard²⁷, Thaddeus S Nowak Jr²⁸, Anant B Patel²⁹, Caroline D Rae³⁰, Timothy A Ryan³¹, Patricia F Schuck¹⁴, Ian A Simpson³², Susan J Vannucci³³, Helle S Waagepetersen³⁴, Gary Yellen³⁵, Mary C McKenna³⁶

Affiliations

¹ Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
² Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
³ Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
⁴ Translational Research Center (TRACE), Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
⁵ Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
⁶ Faculty of Health, Medicine and Behavioural Sciences, School of Biomedical Sciences, University of Queensland, Brisbane, Australia.
⁷ Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
⁸ School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.
⁹ Institute of Anatomy II, University of Frankfurt, Frankfurt/M, Germany.
¹⁰ Department of Biochemistry and Physiology, Center for Geroscience and Healthy Brain Aging, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
¹¹ Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
¹² Department of Experimental Medical Science, Lund University, Lund, Sweden.
¹³ Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.
¹⁴ Laboratorio de Erros Inatos Do Metabolismo, Instituto de Bioquimica Medica Leopoldo de Meis, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
¹⁵ Centro Ricerche Enrico Fermi and Fondazione Santa Lucia, Rome, Italy.
¹⁶ Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
¹⁷ Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
¹⁸ Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
¹⁹ Biomedical Engineering, Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
²⁰ Faculty of Medicine & Dentistry, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
²¹ Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.
²² Veterans Health Care System Baltimore, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
²³ Department of Biomedical & Pharmaceutical Sciences, Idaho State University College of Pharmacy, Pocatello, Idaho, USA.
²⁴ Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA.
²⁵ Yale University, New Haven, Connecticut, USA.
²⁶ Behavioral Neuroscience, University at Albany, Albany, New York, USA.
²⁷ Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA.
²⁸ Department of Neurology, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁹ CSIR-Center for Cellular and Molecular Biology, Hyderabad, India.
³⁰ School of Psychology, UNSW Sydney, Neuroscience Research Australia, Randwick, New South Wales, Australia.
³¹ Department of Biochemistry & Biophysics, Weill Cornell Medicine, New York, New York, USA.
³² Neural and Behavioral Sciences, College of Medicine, Penn State University, MC, USA.
³³ Department of Pediatrics and Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
³⁴ University of Southern Denmark, Odense, Denmark.
³⁵ Harvard Medical School, Department of Neurobiology, Boston, Massachusetts, USA.
³⁶ Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA.

PMID: 40966093
DOI: 10.1111/jnc.70230

Embracing Scientific Debate in Brain Metabolism

Jens V Andersen et al. J Neurochem. 2025 Sep.

. 2025 Sep;169(9):e70230.

doi: 10.1111/jnc.70230.

Authors

Affiliations

¹ Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
² Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
³ Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
⁴ Translational Research Center (TRACE), Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
⁵ Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
⁶ Faculty of Health, Medicine and Behavioural Sciences, School of Biomedical Sciences, University of Queensland, Brisbane, Australia.
⁷ Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
⁸ School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.
⁹ Institute of Anatomy II, University of Frankfurt, Frankfurt/M, Germany.
¹⁰ Department of Biochemistry and Physiology, Center for Geroscience and Healthy Brain Aging, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
¹¹ Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
¹² Department of Experimental Medical Science, Lund University, Lund, Sweden.
¹³ Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.
¹⁴ Laboratorio de Erros Inatos Do Metabolismo, Instituto de Bioquimica Medica Leopoldo de Meis, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
¹⁵ Centro Ricerche Enrico Fermi and Fondazione Santa Lucia, Rome, Italy.
¹⁶ Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
¹⁷ Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
¹⁸ Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
¹⁹ Biomedical Engineering, Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
²⁰ Faculty of Medicine & Dentistry, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
²¹ Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.
²² Veterans Health Care System Baltimore, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
²³ Department of Biomedical & Pharmaceutical Sciences, Idaho State University College of Pharmacy, Pocatello, Idaho, USA.
²⁴ Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA.
²⁵ Yale University, New Haven, Connecticut, USA.
²⁶ Behavioral Neuroscience, University at Albany, Albany, New York, USA.
²⁷ Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA.
²⁸ Department of Neurology, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁹ CSIR-Center for Cellular and Molecular Biology, Hyderabad, India.
³⁰ School of Psychology, UNSW Sydney, Neuroscience Research Australia, Randwick, New South Wales, Australia.
³¹ Department of Biochemistry & Biophysics, Weill Cornell Medicine, New York, New York, USA.
³² Neural and Behavioral Sciences, College of Medicine, Penn State University, MC, USA.
³³ Department of Pediatrics and Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
³⁴ University of Southern Denmark, Odense, Denmark.
³⁵ Harvard Medical School, Department of Neurobiology, Boston, Massachusetts, USA.
³⁶ Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA.

PMID: 40966093
DOI: 10.1111/jnc.70230

Abstract

Brain metabolism is a fascinating and exciting research topic. Many new metabolic features of the brain continue to be unveiled and much remains to be discovered. To truly enable scientific progress, it is imperative that discoveries and theories are continually challenged through scholarly discussion. Here we address an earlier editorial by Bolaños et al. 2025 to underline the importance of embracing and respectfully engaging in scientific debate.

Keywords: metabolic shuttles; metabolism; neuron–glia interactions.

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Embracing Scientific Debate in Brain Metabolism

Affiliations

Embracing Scientific Debate in Brain Metabolism

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources