The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Affiliations

¹ Department of Health Data Sciences and Biostatistics, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA; Department of Immunology, School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: lindsay.cowell@utsouthwestern.edu.
² Department of Health Data Sciences and Biostatistics, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA.
³ Department of Biological Sciences, Faculty of Science, Simon Fraser University, Burnaby, BC, Canada.
⁴ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
⁵ Clareo Biosciences Inc., Louisville, KY, USA.
⁶ Knocean Inc., Toronto, ON, Canada.
⁷ Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
⁸ Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
⁹ Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

PMID: 40967183
DOI: 10.1016/j.cels.2025.101401

The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Lindsay G Cowell et al. Cell Syst. 2025.

. 2025 Sep 17;16(9):101401.

doi: 10.1016/j.cels.2025.101401.

Authors

Affiliations

¹ Department of Health Data Sciences and Biostatistics, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA; Department of Immunology, School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: lindsay.cowell@utsouthwestern.edu.
² Department of Health Data Sciences and Biostatistics, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA.
³ Department of Biological Sciences, Faculty of Science, Simon Fraser University, Burnaby, BC, Canada.
⁴ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
⁵ Clareo Biosciences Inc., Louisville, KY, USA.
⁶ Knocean Inc., Toronto, ON, Canada.
⁷ Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
⁸ Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
⁹ Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

PMID: 40967183
DOI: 10.1016/j.cels.2025.101401

Abstract

Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.

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Conflict of interest statement

Declaration of interests B.C. and F.B. are partners in and consultants for iReceptor Genomic Services. C.T.W. and W.L. are founders and shareholders of Clareo Biosciences Inc. and serve on its executive board.

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The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Affiliations

The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources