Antitumor activity of phenyl substituted dihalogenobis (1-phenyl-1,3-butanedionato)titanium (IV) compounds

Abstract

14 phenyl substituated dihalogenobis(1-phenyl-1.3-butanedionato)titanium(IV) compounds were synthesized and characterized by their elemental analyses, IR and/or H-NMR spectra. Their antitumor activity was tested using the intraperitoneally transplanted sarkoma 180 tumor system in mice. Cisplatin was used in several doses as positive control compound. Compared to the recently discovered activity of dihalogenobis(1-phenyl-1.3-butanedionato)titanium (IV) agents, most of the new materials have similar antineoplastic effects. The ratio of median survival time of treated to untreated control animals ranged up to 300% for these compounds. Significance according to Kruskal-Wallis-Test and long-time survivors are given. The possible mechanism of action compared to cisplatin is discussed.