A need for new tools for prevention of malaria in pregnancy
- PMID: 40971346
- PMCID: PMC12448331
- DOI: 10.1371/journal.pmed.1004729
A need for new tools for prevention of malaria in pregnancy
Abstract
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is a chemoprevention strategy against malaria in pregnancy. A recent PLOS Medicine study highlights the need for better understanding of the mechanism by which IPTp-SP reduces low birthweight, as well as novel measures to prevent malaria earlier in gestation.
Copyright: © 2025 Saito, McGready. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Conflict of interest statement
The authors have declared that no competing interests exist.
Comment on
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Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda.PLoS Med. 2025 Sep 18;22(9):e1004582. doi: 10.1371/journal.pmed.1004582. eCollection 2025 Sep. PLoS Med. 2025. PMID: 40966190 Free PMC article. Clinical Trial.
References
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- World Health Organization. World Malaria Report 2024. Geneva: WHO Press; 2024.
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- Gilder ME, Saito M, Haohankhunnatham W, Ling CL, Gornsawun G, Bancone G, et al. Submicroscopic malaria in pregnancy and associated adverse pregnancy events: a case-cohort study of 4,352 women on the Thailand-Myanmar border. PLoS Med. 2025;22(3):e1004529. doi: 10.1371/journal.pmed.1004529 - DOI - PMC - PubMed
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- van Eijk AM, Stepniewska K, Khairallah C, Rodriguez E, Ahn J, Gutman JR. The impact of sulfadoxine–pyrimethamine resistance on the effectiveness of intermittent preventive treatment for the prevention of malaria in pregnancy in Africa: an updated systematic review and meta-analysis. Lancet Infect Dis. 2025. doi: 10.1016/S473-3099(25)00219-1 - DOI - PMC - PubMed
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- Roh ME, Gutman JR, Murphy M, Hill J, Madanitsa M, Kakuru A, et al. Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis. eClinicalMedicine. 2025;83:103202. - PMC - PubMed
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