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. 2025 Nov;100(11):2114-2117.
doi: 10.1002/ajh.70077. Epub 2025 Sep 20.

Optical Genome Mapping (OGM): Validation and Clinical Utility in the Cytogenetic Diagnosis of Multiple Myeloma

Adela Cisneros  1   2 , Mar Mallo  3   4 , Aleix Méndez-López  2 , Carmen Villena  2 , Encarnación Santafé  2 , Jessica Tijero  4 , Maria Abel  4 , Neus Ruiz-Xivillé  2 , Gladys Ibarra  2 , Laura Abril  2 , Anna M Sureda  5 , Lourdes Escoda  6 , Yolanda González-Montes  7 , Xavier Ortín  8 , Jose T Navarro  1   2 , Albert Oriol  1   2 , Francesc Solé  3 , Isabel Granada  2
Affiliations

Optical Genome Mapping (OGM): Validation and Clinical Utility in the Cytogenetic Diagnosis of Multiple Myeloma

Adela Cisneros et al. Am J Hematol. 2025 Nov.

Abstract

Diagram illustrating the final OGM assessment in relation to targeted FISH analysis. On the right, the final OGM results indicate whether additional alterations were detected, no alterations were observed, genetic diagnosis was improved, or if results were inconclusive, including cases where FISH and OGM showed no concordance and OGM did not reveal any alterations.

Keywords: FISH; OGM; cytogenetics; multiple myeloma.

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