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. 2025 Jun 30;21(6):1501-1505.
doi: 10.6026/973206300211501. eCollection 2025.

In vitro assessment of cytokine release from gingival fibroblasts exposed to periodontal pathogens

Kaushal Pati Tripathi  1 , Rohit Mishra  1 , Varsha Choubey  1 , Ajay Kumar  2 , Arohi Aglawe  3 , Anshul Gulati  1
Affiliations

In vitro assessment of cytokine release from gingival fibroblasts exposed to periodontal pathogens

Kaushal Pati Tripathi et al. Bioinformation. .

Abstract

Cytokine responses of gingival fibroblasts from healthy and inflamed tissues upon exposure to P. gingivalis lipopolysaccharide (LPS) are of interest. Samples were obtained from 20 individuals undergoing periodontal procedures. Inflamed fibroblasts showed elevated secretion of IL-6, MCP-1, IL-8, and GRO. P. gingivalis LPS induced a stronger cytokine response than controls. Thus, inflamed fibroblasts can mount a secondary inflammatory response to periodontal pathogens.

Keywords: Gingival fibroblasts; cytokines; inflamed gingiva; periopathogens.

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