Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 7:3:1291471.
doi: 10.3389/fdsfr.2023.1291471. eCollection 2023.

Promising treatment biomarkers in asthma

Affiliations
Review

Promising treatment biomarkers in asthma

Barbara Bonnesen et al. Front Drug Saf Regul. .

Abstract

Asthma is a highly heterogenous disease which researchers over time have attempted to classify into different phenotypes and endotypes to improve diagnosis, prognosis and treatment. Earlier classifications based on reaction to environmental allergens, age, sex and lung function have evolved, and today, the use of precision medicine guided by biomarkers offers new perspectives on asthma management. Identifying biomarkers that may reveal the underlying pathophysiology of the disease will help to select the patients who will benefit most from specific treatments. This review explores the classification of asthma phenotypes and focuses on the most recent advances in using biomarkers to guide treatment.

Keywords: asthma; asthma treatment; biomarker; personalized medicine; phenotype.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Akar-Ghibril N., Casale T., Custovic A., Phipatanakul W. (2020). Allergic endotypes and phenotypes of asthma. J. Allergy Clin. Immunol. Pract. 8 (2), 429–440. 10.1016/j.jaip.2019.11.008 - DOI - PMC - PubMed
    1. Alavinezhad A., Ghorani V., Rajabi O., Boskabady M. H. (2022). Zataria multiflora extract influenced asthmatic patients by improving respiratory symptoms, pulmonary function tests and lung inflammation. J. Ethnopharmacol. 285, 114888. 10.1016/j.jep.2021.114888 - DOI - PubMed
    1. Asthma G. I. f. (2022). Global strategy for asthma management and prevention. Available from: www.ginasthma.org.
    1. Austin C. D., Gonzalez Edick M., Ferrando R. E., Solon M., Baca M., Mesh K., et al. (2020). A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER). Clin. Exp. Allergy 50 (12), 1342–1351. 10.1111/cea.13731 - DOI - PMC - PubMed
    1. Ayars A. G., Altman L. C., Potter-Perigo S., Radford K., Wight T. N., Nair P. (2013). Sputum hyaluronan and versican in severe eosinophilic asthma. Int. Arch. Allergy Immunol. 161 (1), 65–73. 10.1159/000343031 - DOI - PMC - PubMed

LinkOut - more resources