Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Sep 8;7(5):fcaf328.
doi: 10.1093/braincomms/fcaf328. eCollection 2025.

High frequency opportunities for Alzheimer's disease

Christos Panagiotis Lisgaras  1   2
Affiliations
Comment

High frequency opportunities for Alzheimer's disease

Christos Panagiotis Lisgaras. Brain Commun. .

Abstract

This scientific commentary refers to 'High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations', by Shandilya et al. (https://doi.org/10.1093/braincomms/fcaf041).

PubMed Disclaimer

Conflict of interest statement

The authors report no competing interests.

Figures

Figure 1
Figure 1
Comparison of conventional versus wideband EEG in detecting HFOs and IEDs. The upper trace shows a signal sampled at 500 Hz with a 1–70 Hz bandpass filter, representative of a conventional EEG setting. An IED (marked by a black arrow) is visible, but no HFO activity is detected (IED+, HFO−). The lower trace shows a signal recorded using wideband settings (2000 Hz sampling rate; 0.1–500 Hz bandpass filter). Several HFOs (marked by asterisks) are now evident, along with the same IED (IED+, HFO+). The signal comes from a mouse model of temporal lobe epilepsy (intrahippocampal kainic acid model) and is shown for illustrative purposes. The top trace was generated by downsampling and filtering the original wideband signal shown in the bottom trace.
See this image and copyright information in PMC

Comment on

References

    1. Palop JJ, Chin J, Mucke L. A network dysfunction perspective on neurodegenerative diseases. Nature. 2006;443(7113):768–773. - PubMed
    1. Vossel KA, Ranasinghe KG, Beagle AJ, et al. Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Ann Neurol. 2016;80(6):858–870. - PMC - PubMed
    1. Zijlmans M, Jiruska P, Zelmann R, Leijten FSS, Jefferys JGR, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012;71(2):169–178. - PMC - PubMed
    1. Lisgaras CP, Scharfman HE. High frequency oscillations (250–500Hz) in animal models of Alzheimer's disease and two animal models of epilepsy. Epilepsia. 2023;64(1):231–246. - PMC - PubMed
    1. Shandilya MCV, Addo-Osafo K, Ranasinghe KG, et al. High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations. Brain Commun. 2025;7(1):fcaf041. - PMC - PubMed

LinkOut - more resources