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Case Reports
. 2025 Jul 10;12(9):ofaf402.
doi: 10.1093/ofid/ofaf402. eCollection 2025 Sep.

First Case of Neuroinvasive Oropouche Virus in Wisconsin: A Case Report

Caroline B Ewing  1 , Dawd Siraj  1 , Alexander Lepak  1
Affiliations
Case Reports

First Case of Neuroinvasive Oropouche Virus in Wisconsin: A Case Report

Caroline B Ewing et al. Open Forum Infect Dis. .

Abstract

Per the Pan American Health Organization/World Health Organization, Oropouche virus (OROV) is a reemerging arbovirus that poses a yet undetermined degree of threat to the United States, with outbreaks reported in the Caribbean and South America, including new areas of spread, since the end of 2023 and, at this time, there exists no vaccine or disease-specific treatment. Here we describe the presentation and diagnosis of a neuroinvasive case of OROV, the first documented case of OROV in Wisconsin, the first documented case in the United States in 2025, and the first documented US case associated with travel to Panama.

Keywords: OROV; Oropouche virus; neuroinvasive virus; reemerging virus; sloth fever.

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References

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