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. 1970 Nov 21;4(5733):463-5.
doi: 10.1136/bmj.4.5733.463.

Secretory IgA in urinary tract infections

D B Kaufman, R Katz, R M McIntosh

Secretory IgA in urinary tract infections

D B Kaufman et al. Br Med J. .

Abstract

Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals-3.3 to 0.78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.

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