Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings

Ronald Galiwango^{1

2

3}, Christopher J Whalen^{4

5}, Grace Kebirungi^{1

2

3}, Mugume T Atwine^{1

2

3}, Rodgers Kimera^{1

5}, Alfred Ssekagiri^{3

6}, Timothy W Kimbowa^{3

6}, Edward Lukyamuzi^{3

6}, Mike Nsubuga^{1

2

3}; eLwazi ODSP; Lloyd Ssentongo⁵, Henry Mutegeki^{1

2}, John M Fonner⁷, Frank Wuerthwein⁸, Ari Berman⁹, Laura B Okalebo⁹, Meghan McCarthy⁴, Victor S Kramer⁴, Mariam Quinones⁴, Phillip Cruz⁴, Darrell Hurt⁴, Maria Y Giovanni⁴, Nicola Mulder^{3

10}, Michael Tartakovsky⁴, Jonathan Kayondo^{3

6}, Daudi Jjingo^{1

2

3

11}

Affiliations

¹ The African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Kampala, Uganda.
² The Infectious Diseases Institute (IDI), Makerere University, Kampala, Uganda.
³ Open Data Science Platform (ODSP) for the DS-I Africa (Data Science Initiative for Africa), University of Cape Town, Cape Town, South Africa.
⁴ Office of Cyber Infrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
⁵ Research Data and Communication Technologies Benefit Corp., Garrett Park, Maryland, United States of America.
⁶ Uganda Virus Research Institute (UVRI), Entebbe, Uganda.
⁷ Texas Advanced Computing Center (TACC), University of Texas at Austin, Austin, Texas, United States of America.
⁸ University of California San Diego, La Jolla, California, United States of America.
⁹ BioTeam, Middleton, Massachusetts, United States of America.
¹⁰ Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, University of Cape Town, Cape Town, South Africa.
¹¹ Department of Computer Science, College of Computing and Information Sciences, Makerere University, Kampala, Uganda.

Ronald Galiwango et al. PLoS Comput Biol. 2025.

. 2025 Sep 22;21(9):e1013481.

doi: 10.1371/journal.pcbi.1013481. eCollection 2025 Sep.

¹ The African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Kampala, Uganda.
² The Infectious Diseases Institute (IDI), Makerere University, Kampala, Uganda.
³ Open Data Science Platform (ODSP) for the DS-I Africa (Data Science Initiative for Africa), University of Cape Town, Cape Town, South Africa.
⁴ Office of Cyber Infrastructure and Computational Biology (OCICB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
⁵ Research Data and Communication Technologies Benefit Corp., Garrett Park, Maryland, United States of America.
⁶ Uganda Virus Research Institute (UVRI), Entebbe, Uganda.
⁷ Texas Advanced Computing Center (TACC), University of Texas at Austin, Austin, Texas, United States of America.
⁸ University of California San Diego, La Jolla, California, United States of America.
⁹ BioTeam, Middleton, Massachusetts, United States of America.
¹⁰ Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, University of Cape Town, Cape Town, South Africa.
¹¹ Department of Computer Science, College of Computing and Information Sciences, Makerere University, Kampala, Uganda.

No abstract available

Conflict of interest statement

The authors have declared that no competing interests exist.

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