Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep 22.
doi: 10.1038/s41577-025-01228-4. Online ahead of print.

Clearing the hurdles for CAR-T cell treatment

Affiliations

Clearing the hurdles for CAR-T cell treatment

Rayne H Rouce. Nat Rev Immunol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: R.H.R. is a member of the Leukemia and Lymphoma Society board of directors and previous member of the National Marrow Donor Program Board and American Society of Gene and Cell Therapy board of directors.

References

    1. Schuster, S. J. et al. Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma. N. Engl. J. Med. 380, 45–56 (2019). - DOI - PubMed
    1. Maude, S. L. et al. Tisagenlecleucel in children and young adults with b-cell lymphoblastic leukemia. N. Engl. J. Med. 378, 439–448 (2018). - DOI - PubMed - PMC
    1. John, S. et al. Real-world data for tisagenlecleucel in patients with R/R B-ALL: subgroup analyses from the CIBMTR registry. Blood Adv. https://doi.org/10.1182/bloodadvances.2025015881 (2025). - DOI - PubMed - PMC
    1. Rouce, R. H. & Porteus, M. H. Cell and gene therapy accessibility. Science 385, 475 (2024). - DOI - PubMed
    1. Rouce, R. H. & Grilley, B. J. How to democratize cell and gene therapy: a global approach. Mol. Ther. 33, 2082–2090 (2025). - DOI - PubMed