Gene-edited CAR T cells: going the distance in B-ALL
- PMID: 40986309
- PMCID: PMC12496417
- DOI: 10.1182/bloodadvances.2025017508
Gene-edited CAR T cells: going the distance in B-ALL
Conflict of interest statement
Comment on
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Long-term outcomes of genome-edited "universal" CAR19 T cells for relapsed/refractory B-ALL at a single pediatric center.Blood Adv. 2025 Sep 23;9(18):4750-4754. doi: 10.1182/bloodadvances.2025016366. Blood Adv. 2025. PMID: 40601899 Free PMC article.
References
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- Guardo D, Mishra AK, Rashed H, et al. Long term outcomes of genome edited 'universal' CAR19 T-cells for relapsed/refractory B-ALL at a single pediatric centre. Blood Adv. 2025;9(18):4750–4754. - PubMed
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- Qasim W, Zhan H, Samarasinghe S, et al. Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Sci Transl Med. 2017;9(374) - PubMed
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- Ottaviano G, Georgiadis C, Gkazi SA, et al. Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia. Sci Transl Med. 2022;14(668) - PubMed
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