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. 1970 Sep;20(3):465-8.
doi: 10.1128/am.20.3.465-468.1970.

Anticomplementary, anticoagulatory, and serum-protein precipitating activity of sodium polyanetholsulfonate

W H Traub, B L Lowrance

Anticomplementary, anticoagulatory, and serum-protein precipitating activity of sodium polyanetholsulfonate

W H Traub et al. Appl Microbiol. 1970 Sep.

Abstract

Sodium polyanetholsulfonate (SPS) at 7.8 mug/ml completely abolished complement-mediated hemolysis of 1:10 diluted fresh guinea pig and human serum; at least twice as much SPS was required to reduce complement activity in 1:2 diluted human serum. The coagulation of 90 and 20% human blood was inhibited by 250 and 125 mug of SPS per ml, respectively. When added to fresh human serum, SPS precipitated beta 1C-globulin (C3), C4, beta lipoproteins, immunoglobulin IgG, IgM, and IgA, though incompletely.

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References

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