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. 2025 Sep 23.
doi: 10.1097/DAD.0000000000003129. Online ahead of print.

Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review

Taylor E Arnoff  1 , Nicholas Gessner  1 , Fatima N Mirza  2 , Dean David George  3 , Leslie Robinson-Bostom  2
Affiliations

Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review

Taylor E Arnoff et al. Am J Dermatopathol. .

Abstract

Monoclonal cryoglobulinemia commonly presents with cutaneous manifestations and develops almost exclusively in the setting of an underlying lymphoproliferative or hematologic disorder of B-cell lineage. Herein, we describe a case of a 48-year-old woman who presented with a recurrent and symmetric hemorrhagic papular eruption. Punch biopsy and direct immunofluorescence were consistent with monoclonal cryoglobulinemia. Systemic workup was notable for elevated kappa free light chains with a monoclonal immunoglobulin M kappa component on serum protein electrophoresis, and bone marrow biopsy was consistent with lymphoplasmacytic lymphoma.

Keywords: lymphoplasmacytic lymphoma; monoclonal cryoglobulinemia.

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Conflict of interest statement

The authors declare no conflicts of interest.

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